Cross-reactivity of suppressor T cells specific for lactate dehydrogenase B and IgG2a myeloma protein

Z. A. Nagy, C. N. Baxevanis, J. Klein

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The major histocompatibility complex-controlled immune responsiveness of mice to two unrelated antigens, lactate dehydrogenase B (LDH(B)) and IgG2a myeloma protein is remarkably similar. The similarity is explained by our recent work, demonstrating that both antigens, when presented in the context of cell surface E(k) (E(α)(k)E(β)(k)) molecules, generate strong suppression that causes nonresponsiveness to all mouse strains expressing this molecule. The suppression is mediated by antigen-specific, E(k)-restricted Lyt-1+2+ suppressor T (Ts) cells, which act by inhibiting the proliferation of A(A(α)A(β))-restricted, Lyt-1+2- (possibly T helper [Th]) cells specific for the same antigen. However, the question of why the E(k) molecule, in combination with two structurally unrelated proteins, preferentially induces Ts cells has remained unanswered. We demonstrate here that the anti-LDH(B) and anti-IgG2a Ts cells are fully cross-reactive, which indicates that the LDH(B) + E(k) and IgG2a + E(k) determinants recognized by these cells are very similar or identical.

Original languageEnglish (US)
Pages (from-to)1498-1499
Number of pages2
JournalJournal of Immunology
Volume130
Issue number4
StatePublished - Jan 1 1983

Fingerprint

Myeloma Proteins
T-Lymphocytes
Antigens
Th2 Cells
Major Histocompatibility Complex
lactate dehydrogenase 1
Proteins

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Nagy, Z. A. ; Baxevanis, C. N. ; Klein, J. / Cross-reactivity of suppressor T cells specific for lactate dehydrogenase B and IgG2a myeloma protein. In: Journal of Immunology. 1983 ; Vol. 130, No. 4. pp. 1498-1499.
@article{1e8c5af8934045a9a9af5353200f71f7,
title = "Cross-reactivity of suppressor T cells specific for lactate dehydrogenase B and IgG2a myeloma protein",
abstract = "The major histocompatibility complex-controlled immune responsiveness of mice to two unrelated antigens, lactate dehydrogenase B (LDH(B)) and IgG2a myeloma protein is remarkably similar. The similarity is explained by our recent work, demonstrating that both antigens, when presented in the context of cell surface E(k) (E(α)(k)E(β)(k)) molecules, generate strong suppression that causes nonresponsiveness to all mouse strains expressing this molecule. The suppression is mediated by antigen-specific, E(k)-restricted Lyt-1+2+ suppressor T (Ts) cells, which act by inhibiting the proliferation of A(A(α)A(β))-restricted, Lyt-1+2- (possibly T helper [Th]) cells specific for the same antigen. However, the question of why the E(k) molecule, in combination with two structurally unrelated proteins, preferentially induces Ts cells has remained unanswered. We demonstrate here that the anti-LDH(B) and anti-IgG2a Ts cells are fully cross-reactive, which indicates that the LDH(B) + E(k) and IgG2a + E(k) determinants recognized by these cells are very similar or identical.",
author = "Nagy, {Z. A.} and Baxevanis, {C. N.} and J. Klein",
year = "1983",
month = "1",
day = "1",
language = "English (US)",
volume = "130",
pages = "1498--1499",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "4",

}

Cross-reactivity of suppressor T cells specific for lactate dehydrogenase B and IgG2a myeloma protein. / Nagy, Z. A.; Baxevanis, C. N.; Klein, J.

In: Journal of Immunology, Vol. 130, No. 4, 01.01.1983, p. 1498-1499.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cross-reactivity of suppressor T cells specific for lactate dehydrogenase B and IgG2a myeloma protein

AU - Nagy, Z. A.

AU - Baxevanis, C. N.

AU - Klein, J.

PY - 1983/1/1

Y1 - 1983/1/1

N2 - The major histocompatibility complex-controlled immune responsiveness of mice to two unrelated antigens, lactate dehydrogenase B (LDH(B)) and IgG2a myeloma protein is remarkably similar. The similarity is explained by our recent work, demonstrating that both antigens, when presented in the context of cell surface E(k) (E(α)(k)E(β)(k)) molecules, generate strong suppression that causes nonresponsiveness to all mouse strains expressing this molecule. The suppression is mediated by antigen-specific, E(k)-restricted Lyt-1+2+ suppressor T (Ts) cells, which act by inhibiting the proliferation of A(A(α)A(β))-restricted, Lyt-1+2- (possibly T helper [Th]) cells specific for the same antigen. However, the question of why the E(k) molecule, in combination with two structurally unrelated proteins, preferentially induces Ts cells has remained unanswered. We demonstrate here that the anti-LDH(B) and anti-IgG2a Ts cells are fully cross-reactive, which indicates that the LDH(B) + E(k) and IgG2a + E(k) determinants recognized by these cells are very similar or identical.

AB - The major histocompatibility complex-controlled immune responsiveness of mice to two unrelated antigens, lactate dehydrogenase B (LDH(B)) and IgG2a myeloma protein is remarkably similar. The similarity is explained by our recent work, demonstrating that both antigens, when presented in the context of cell surface E(k) (E(α)(k)E(β)(k)) molecules, generate strong suppression that causes nonresponsiveness to all mouse strains expressing this molecule. The suppression is mediated by antigen-specific, E(k)-restricted Lyt-1+2+ suppressor T (Ts) cells, which act by inhibiting the proliferation of A(A(α)A(β))-restricted, Lyt-1+2- (possibly T helper [Th]) cells specific for the same antigen. However, the question of why the E(k) molecule, in combination with two structurally unrelated proteins, preferentially induces Ts cells has remained unanswered. We demonstrate here that the anti-LDH(B) and anti-IgG2a Ts cells are fully cross-reactive, which indicates that the LDH(B) + E(k) and IgG2a + E(k) determinants recognized by these cells are very similar or identical.

UR - http://www.scopus.com/inward/record.url?scp=0020567944&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020567944&partnerID=8YFLogxK

M3 - Article

C2 - 6187807

AN - SCOPUS:0020567944

VL - 130

SP - 1498

EP - 1499

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 4

ER -