Cross-species comparisons of host genetic associations with the microbiome

Julia K. Goodrich, Emily R. Davenport, Jillian L. Waters, Andrew G. Clark, Ruth E. Ley

Research output: Contribution to journalReview article

94 Citations (Scopus)

Abstract

Recent studies in human populations and mouse models reveal notable congruences in gut microbial taxa whose abundances are partly regulated by host genotype. Host genes associating with these taxa are related to diet sensing, metabolism, and immunity.These broad patterns are further validated in similar studies of nonmammalian microbiomes.The next generation of genome-wide association studies will expand the size of the data sets and refine the microbial phenotypes to fully capture these intriguing signatures of host-microbiome coevolution.

Original languageEnglish (US)
Pages (from-to)532-535
Number of pages4
JournalScience
Volume352
Issue number6285
DOIs
StatePublished - Apr 29 2016

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Microbiota
Genome-Wide Association Study
Immunity
Genotype
Diet
Phenotype
Population
Genes
Datasets

All Science Journal Classification (ASJC) codes

  • General

Cite this

Goodrich, Julia K. ; Davenport, Emily R. ; Waters, Jillian L. ; Clark, Andrew G. ; Ley, Ruth E. / Cross-species comparisons of host genetic associations with the microbiome. In: Science. 2016 ; Vol. 352, No. 6285. pp. 532-535.
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Goodrich, JK, Davenport, ER, Waters, JL, Clark, AG & Ley, RE 2016, 'Cross-species comparisons of host genetic associations with the microbiome', Science, vol. 352, no. 6285, pp. 532-535. https://doi.org/10.1126/science.aad9379

Cross-species comparisons of host genetic associations with the microbiome. / Goodrich, Julia K.; Davenport, Emily R.; Waters, Jillian L.; Clark, Andrew G.; Ley, Ruth E.

In: Science, Vol. 352, No. 6285, 29.04.2016, p. 532-535.

Research output: Contribution to journalReview article

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