TY - JOUR
T1 - Cross-species septal transplants
T2 - recovery of choline acetyltransferase activity
AU - Daniloff, Joanne Kelsch
AU - Wells, Joseph
AU - Ellis, John
N1 - Funding Information:
We are grateful for the assistance of Drs. P. R. Hoffman, W. C. Low, E. D. Hendley, and M. A. Ariano. Research supported by PHS Grant no. 5429-17-3 and a grant from the American Federation for Aging Research.
PY - 1984/12/17
Y1 - 1984/12/17
N2 - Following interruption of the fornix-fimbria pathway, hippocampal choline acetyltransferase (ChAT) activity was restored gradually by cross-species cell suspension transplants of embryonic septum. The hippocampal segment closest to the implant reached 35% of normal 17 weeks after transplantation. The overall restoration of ChAT by xenogenic cell suspension had many similarities to that reported for homogenic solid and cell suspension septal grafts. The time course of the recovery of ChAT activity was different from the time course of the ingrowth of acetylcholinesterase stained fibers reported previously.
AB - Following interruption of the fornix-fimbria pathway, hippocampal choline acetyltransferase (ChAT) activity was restored gradually by cross-species cell suspension transplants of embryonic septum. The hippocampal segment closest to the implant reached 35% of normal 17 weeks after transplantation. The overall restoration of ChAT by xenogenic cell suspension had many similarities to that reported for homogenic solid and cell suspension septal grafts. The time course of the recovery of ChAT activity was different from the time course of the ingrowth of acetylcholinesterase stained fibers reported previously.
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U2 - 10.1016/0006-8993(84)90634-6
DO - 10.1016/0006-8993(84)90634-6
M3 - Article
C2 - 6518386
AN - SCOPUS:0021681970
VL - 324
SP - 151
EP - 154
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -