Crosslink between calcium and sodium signalling

Alexei Verkhratsky, Mohamed Trebak, Fabiana Perocchi, Daniel Khananshvili, Israel Sekler

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

New Findings: What is the topic of this review? This paper overviews the links between Ca2+ and Na+ signalling in various types of cells. What advances does it highlight? This paper highlights the general importance of ionic signalling and overviews the molecular mechanisms linking Na+ and Ca2+ dynamics. In particular, the narrative focuses on the molecular physiology of plasmalemmal and mitochondrial Na+–Ca2+ exchangers and plasmalemmal transient receptor potential channels. Functional consequences of Ca2+ and Na+ signalling for co-ordination of neuronal activity with astroglial homeostatic pathways fundamental for synaptic transmission are discussed. Abstract: Transmembrane ionic gradients, which are an indispensable feature of life, are used for generation of cytosolic ionic signals that regulate a host of cellular functions. Intracellular signalling mediated by Ca2+ and Na+ is tightly linked through several molecular pathways that generate Ca2+ and Na+ fluxes and are in turn regulated by both ions. Transient receptor potential (TRP) channels bridge endoplasmic reticulum Ca2+ release with generation of Na+ and Ca2+ currents. The plasmalemmal Na+–Ca2+ exchanger (NCX) flickers between forward and reverse mode to co-ordinate the influx and efflux of both ions with membrane polarization and cytosolic ion concentrations. The mitochondrial calcium uniporter channel (MCU) and mitochondrial Na+–Ca2+ exchanger (NCLX) mediate Ca2+ entry into and release from this organelle and couple cytosolic Ca2+ and Na+ fluctuations with cellular energetics. Cellular Ca2+ and Na+ signalling controls numerous functional responses and, in the CNS, provides for fast regulation of astroglial homeostatic cascades that are crucial for maintenance of synaptic transmission.

Original languageEnglish (US)
Pages (from-to)157-169
Number of pages13
JournalExperimental Physiology
Volume103
Issue number2
DOIs
StatePublished - Feb 1 2018

Fingerprint

Calcium Signaling
Transient Receptor Potential Channels
Sodium
Ions
Synaptic Transmission
Calcium Channels
Endoplasmic Reticulum
Organelles
Maintenance
Membranes

All Science Journal Classification (ASJC) codes

  • Physiology

Cite this

Verkhratsky, A., Trebak, M., Perocchi, F., Khananshvili, D., & Sekler, I. (2018). Crosslink between calcium and sodium signalling. Experimental Physiology, 103(2), 157-169. https://doi.org/10.1113/EP086534
Verkhratsky, Alexei ; Trebak, Mohamed ; Perocchi, Fabiana ; Khananshvili, Daniel ; Sekler, Israel. / Crosslink between calcium and sodium signalling. In: Experimental Physiology. 2018 ; Vol. 103, No. 2. pp. 157-169.
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Verkhratsky, A, Trebak, M, Perocchi, F, Khananshvili, D & Sekler, I 2018, 'Crosslink between calcium and sodium signalling', Experimental Physiology, vol. 103, no. 2, pp. 157-169. https://doi.org/10.1113/EP086534

Crosslink between calcium and sodium signalling. / Verkhratsky, Alexei; Trebak, Mohamed; Perocchi, Fabiana; Khananshvili, Daniel; Sekler, Israel.

In: Experimental Physiology, Vol. 103, No. 2, 01.02.2018, p. 157-169.

Research output: Contribution to journalReview article

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AU - Trebak, Mohamed

AU - Perocchi, Fabiana

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Verkhratsky A, Trebak M, Perocchi F, Khananshvili D, Sekler I. Crosslink between calcium and sodium signalling. Experimental Physiology. 2018 Feb 1;103(2):157-169. https://doi.org/10.1113/EP086534