Antiserum (A.TL × A.SW)F1 anti-A.TH is specific for the products of the Qa-1a region. It reacts only weakly or under certain circumstances, not at all with the immunizing cells, but it reacts strongly with 100% of H-2f and H-2P lymphocytes. The molecules that are the target of this strong heteroclitic reactivity are controlled by a gene in the K region, most likely the K locus itself. The results are interpreted in terms of crossreactivity of Qa-1-specific antibodies with Class I major histocompatibility complex molecules. This crossreactivity underscores the relatedness of Qa and Class I loci and strengthens the argument that Qa loci are members of the Class I family.
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