Crossreactivity between QA-1 region and H-2K antigens

Felipe Figueroa, Zofia Zaleska-Rutcznyska, Piotr Kusnierczyk, Jan Klein

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Abstract

Antiserum (A.TL × A.SW)F1 anti-A.TH is specific for the products of the Qa-1a region. It reacts only weakly or under certain circumstances, not at all with the immunizing cells, but it reacts strongly with 100% of H-2f and H-2P lymphocytes. The molecules that are the target of this strong heteroclitic reactivity are controlled by a gene in the K region, most likely the K locus itself. The results are interpreted in terms of crossreactivity of Qa-1-specific antibodies with Class I major histocompatibility complex molecules. This crossreactivity underscores the relatedness of Qa and Class I loci and strengthens the argument that Qa loci are members of the Class I family.

Original languageEnglish (US)
Pages (from-to)391-393
Number of pages3
JournalTransplantation
Volume35
Issue number4
DOIs
StatePublished - Apr 1983

All Science Journal Classification (ASJC) codes

  • Transplantation

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    Figueroa, F., Zaleska-Rutcznyska, Z., Kusnierczyk, P., & Klein, J. (1983). Crossreactivity between QA-1 region and H-2K antigens. Transplantation, 35(4), 391-393. https://doi.org/10.1097/00007890-198304000-00025