Cryoablation of benign breast tumors: Evolution of technique and technology

M. Caleffi, D. Duarte Filho, K. Borghetti, M. Graudenz, P. J. Littrup, L. A. Freeman-Gibb, V. J. Zannis, M. J. Schultz, C. S. Kaufman, D. Francescatti, J. S. Smith, R. Simmons, L. Bailey, C. A. Henry, L. H. Stocks

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

We report on improvements in cryoprobe design and techniques of cryoablation as a minimally invasive alternative to open surgery for the treatment of benign breast tumors. In the study, which was conducted in 12 centers, 124 lesions in 102 patients were monitored for a period of 12 months after cryoablation. Two different treatment techniques were used: Double HI FREEZE and Tailored Freeze. In patients treated with the Tailored Freeze technique significantly better results were recorded 12 months after the procedure: the median reduction in tumor volume was 91%, 73% of all tumors treated were nonpalpable, 84% of lesions less than 2.5 cm in maximum diameter were nonpalpable, and none of the 31 mammograms performed yielded abnormal findings. Patient satisfaction was good to excellent in 92% of the patients. The safety profile of this technique was excellent; all complications were minor. Evolution of cryoablation freezing techniques, coupled with improvements in cryoprobe design, has resulted in significant improvements in both safety and effectiveness.

Original languageEnglish (US)
Pages (from-to)397-407
Number of pages11
JournalBreast
Volume13
Issue number5
DOIs
StatePublished - Oct 2004

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Cryosurgery
Breast Neoplasms
Technology
Safety
Tumor Burden
Patient Satisfaction
Freezing
Therapeutics
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Caleffi, M., Filho, D. D., Borghetti, K., Graudenz, M., Littrup, P. J., Freeman-Gibb, L. A., ... Stocks, L. H. (2004). Cryoablation of benign breast tumors: Evolution of technique and technology. Breast, 13(5), 397-407. https://doi.org/10.1016/j.breast.2004.04.008
Caleffi, M. ; Filho, D. Duarte ; Borghetti, K. ; Graudenz, M. ; Littrup, P. J. ; Freeman-Gibb, L. A. ; Zannis, V. J. ; Schultz, M. J. ; Kaufman, C. S. ; Francescatti, D. ; Smith, J. S. ; Simmons, R. ; Bailey, L. ; Henry, C. A. ; Stocks, L. H. / Cryoablation of benign breast tumors : Evolution of technique and technology. In: Breast. 2004 ; Vol. 13, No. 5. pp. 397-407.
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Caleffi, M, Filho, DD, Borghetti, K, Graudenz, M, Littrup, PJ, Freeman-Gibb, LA, Zannis, VJ, Schultz, MJ, Kaufman, CS, Francescatti, D, Smith, JS, Simmons, R, Bailey, L, Henry, CA & Stocks, LH 2004, 'Cryoablation of benign breast tumors: Evolution of technique and technology', Breast, vol. 13, no. 5, pp. 397-407. https://doi.org/10.1016/j.breast.2004.04.008

Cryoablation of benign breast tumors : Evolution of technique and technology. / Caleffi, M.; Filho, D. Duarte; Borghetti, K.; Graudenz, M.; Littrup, P. J.; Freeman-Gibb, L. A.; Zannis, V. J.; Schultz, M. J.; Kaufman, C. S.; Francescatti, D.; Smith, J. S.; Simmons, R.; Bailey, L.; Henry, C. A.; Stocks, L. H.

In: Breast, Vol. 13, No. 5, 10.2004, p. 397-407.

Research output: Contribution to journalArticle

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AU - Bailey, L.

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Caleffi M, Filho DD, Borghetti K, Graudenz M, Littrup PJ, Freeman-Gibb LA et al. Cryoablation of benign breast tumors: Evolution of technique and technology. Breast. 2004 Oct;13(5):397-407. https://doi.org/10.1016/j.breast.2004.04.008