Cryosurgical ablation of the atrioventricular node-His bundle: Long-term follow-up and properties of the junctional pacemaker

G. J. Klein, W. C. Sealy, E. L C Pritchett, L. Harrison, D. B. Hackel, D. Davis, J. Kasell, A. G. Wallace, J. J. Gallagher

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

We used a cryosurgical technique to ablate the atrioventricular (AV) node-His bundle in twenty-two selected patients with disabling supraventricular trachyarrhythmias unresponsive to medical managment. Successful AV block was achieved in seventeen. There was no intraoperative mortality and surgery revealed that the subsidiary pacemaker had a narrow QRS complex morphology and a mean cycle length of 1244 msec. Isoproterenol (1-4 μg/min i.v.) significantly increased (p < 0.01) the rate of the subsidiary pacemaker (mean maximum response 1008.3 msec); atropine (2 mg i.v.) had no effect on its rate. The significant (p = 0.024) increase (mean cycle length 1430 msec). Treadmill exercise in seven patients did not result in the subsidiary pacemaker exceeding the rate of the implanted demand pacemaker set at 70 beats/min. The properties of the subsidiary pacemaker suggest an intra-Hisian site of impulse formation.

Original languageEnglish (US)
Pages (from-to)8-15
Number of pages8
JournalCirculation
Volume61
Issue number1
DOIs
StatePublished - Jan 1 1980

Fingerprint

Bundle of His
Atrioventricular Node
Atrioventricular Block
Atropine
Isoproterenol
Exercise
Mortality

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Klein, G. J., Sealy, W. C., Pritchett, E. L. C., Harrison, L., Hackel, D. B., Davis, D., ... Gallagher, J. J. (1980). Cryosurgical ablation of the atrioventricular node-His bundle: Long-term follow-up and properties of the junctional pacemaker. Circulation, 61(1), 8-15. https://doi.org/10.1161/01.CIR.61.1.8
Klein, G. J. ; Sealy, W. C. ; Pritchett, E. L C ; Harrison, L. ; Hackel, D. B. ; Davis, D. ; Kasell, J. ; Wallace, A. G. ; Gallagher, J. J. / Cryosurgical ablation of the atrioventricular node-His bundle : Long-term follow-up and properties of the junctional pacemaker. In: Circulation. 1980 ; Vol. 61, No. 1. pp. 8-15.
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Klein, GJ, Sealy, WC, Pritchett, ELC, Harrison, L, Hackel, DB, Davis, D, Kasell, J, Wallace, AG & Gallagher, JJ 1980, 'Cryosurgical ablation of the atrioventricular node-His bundle: Long-term follow-up and properties of the junctional pacemaker', Circulation, vol. 61, no. 1, pp. 8-15. https://doi.org/10.1161/01.CIR.61.1.8

Cryosurgical ablation of the atrioventricular node-His bundle : Long-term follow-up and properties of the junctional pacemaker. / Klein, G. J.; Sealy, W. C.; Pritchett, E. L C; Harrison, L.; Hackel, D. B.; Davis, D.; Kasell, J.; Wallace, A. G.; Gallagher, J. J.

In: Circulation, Vol. 61, No. 1, 01.01.1980, p. 8-15.

Research output: Contribution to journalArticle

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T2 - Long-term follow-up and properties of the junctional pacemaker

AU - Klein, G. J.

AU - Sealy, W. C.

AU - Pritchett, E. L C

AU - Harrison, L.

AU - Hackel, D. B.

AU - Davis, D.

AU - Kasell, J.

AU - Wallace, A. G.

AU - Gallagher, J. J.

PY - 1980/1/1

Y1 - 1980/1/1

N2 - We used a cryosurgical technique to ablate the atrioventricular (AV) node-His bundle in twenty-two selected patients with disabling supraventricular trachyarrhythmias unresponsive to medical managment. Successful AV block was achieved in seventeen. There was no intraoperative mortality and surgery revealed that the subsidiary pacemaker had a narrow QRS complex morphology and a mean cycle length of 1244 msec. Isoproterenol (1-4 μg/min i.v.) significantly increased (p < 0.01) the rate of the subsidiary pacemaker (mean maximum response 1008.3 msec); atropine (2 mg i.v.) had no effect on its rate. The significant (p = 0.024) increase (mean cycle length 1430 msec). Treadmill exercise in seven patients did not result in the subsidiary pacemaker exceeding the rate of the implanted demand pacemaker set at 70 beats/min. The properties of the subsidiary pacemaker suggest an intra-Hisian site of impulse formation.

AB - We used a cryosurgical technique to ablate the atrioventricular (AV) node-His bundle in twenty-two selected patients with disabling supraventricular trachyarrhythmias unresponsive to medical managment. Successful AV block was achieved in seventeen. There was no intraoperative mortality and surgery revealed that the subsidiary pacemaker had a narrow QRS complex morphology and a mean cycle length of 1244 msec. Isoproterenol (1-4 μg/min i.v.) significantly increased (p < 0.01) the rate of the subsidiary pacemaker (mean maximum response 1008.3 msec); atropine (2 mg i.v.) had no effect on its rate. The significant (p = 0.024) increase (mean cycle length 1430 msec). Treadmill exercise in seven patients did not result in the subsidiary pacemaker exceeding the rate of the implanted demand pacemaker set at 70 beats/min. The properties of the subsidiary pacemaker suggest an intra-Hisian site of impulse formation.

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