TY - JOUR
T1 - Cryptococcus albidus Fungemia in an Immunosuppressed Child
T2 - Case Report and Systematic Literature Review
AU - Choe, Young June
AU - Blatt, Daniel B.
AU - Yalcindag, Ali
AU - Geffert, Sara F.
AU - Bobenchik, April M.
AU - Michelow, Ian C.
N1 - Funding Information:
Financial support. Research support was provided by the National Institutes of Health, National Institute of Allergy and Infectious Diseases (grant K08 AI100997 to I. C. M.), the National Institute of General Medical Sciences (grant P20GM 104317 to I. C. M.), and the National Institutes of Health, National Institute on Drug Abuse (grant T32DA013911 to S. F. G.).
Publisher Copyright:
© 2019 The Author(s).
PY - 2019/6/11
Y1 - 2019/6/11
N2 - Cryptococcus albidus, synonymous with Naganishia albida, rarely causes opportunistic infection in immunocompromised individuals. Its clinical features, particularly in children, are not well defined. Here, we report a case of C albidus fungemia in an immunosuppressed child; we also present results of a systematic review, for which we searched PubMed, Embase, and Web of Science using the keywords "cryptococcus" and "albidus." Our goal was to describe the spectrum of disease, diagnostic approaches, therapies, and outcomes. We identified 20 cases of invasive infection, only 2 of which involved children, and 7 cases of noninvasive infection. The reports originated in the Americas, Europe, and Asia. Of those with invasive infection, 16 (80%) patients had an underlying chronic disorder or had received immunosuppressive therapy, 8 (40%) had fungemia, and 6 (30%) had a central nervous system infection. The attributable case fatality rate was 40%. C albidus is an opportunistic yeast that can rarely cause life-threatening fungemia and central nervous system infection in individuals of any age, especially those who are immunocompromised.
AB - Cryptococcus albidus, synonymous with Naganishia albida, rarely causes opportunistic infection in immunocompromised individuals. Its clinical features, particularly in children, are not well defined. Here, we report a case of C albidus fungemia in an immunosuppressed child; we also present results of a systematic review, for which we searched PubMed, Embase, and Web of Science using the keywords "cryptococcus" and "albidus." Our goal was to describe the spectrum of disease, diagnostic approaches, therapies, and outcomes. We identified 20 cases of invasive infection, only 2 of which involved children, and 7 cases of noninvasive infection. The reports originated in the Americas, Europe, and Asia. Of those with invasive infection, 16 (80%) patients had an underlying chronic disorder or had received immunosuppressive therapy, 8 (40%) had fungemia, and 6 (30%) had a central nervous system infection. The attributable case fatality rate was 40%. C albidus is an opportunistic yeast that can rarely cause life-threatening fungemia and central nervous system infection in individuals of any age, especially those who are immunocompromised.
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U2 - 10.1093/jpids/piz039
DO - 10.1093/jpids/piz039
M3 - Article
C2 - 31183496
AN - SCOPUS:85081071103
SN - 2048-7193
VL - 9
SP - 100
EP - 105
JO - Journal of the Pediatric Infectious Diseases Society
JF - Journal of the Pediatric Infectious Diseases Society
IS - 1
ER -
