Cryptosporidiosis in a patient with hemophilia, common variable hypogammaglobulinemia, and the acquired immunodeficiency syndrome.

K. L. Koch, T. V. Shankey, G. S. Weinstein, R. E. Dye, A. B. Abt, W. L. Current, M. Elaine Eyster

    Research output: Contribution to journalArticle

    42 Citations (Scopus)

    Abstract

    A 36-year-old man had chronic, debilitating diarrhea due to cryptosporidiosis. This patient had longstanding common variable hypogammaglobulinemia and recurrent bacterial infections. Immunologic evaluation after discovery of Cryptosporidium showed lymphopenia with persistently reduced numbers of helper/inducer cells (OKT-4), variable numbers of suppressor/cytotoxic cells (OKT-8), OKT-4/OKT-8 ratio of 0.09, and increased levels of serum alpha-interferon, all of which describe the acquired immunodeficiency syndrome. Oocysts of Cryptosporidium were found in feces from the patient's cat, thus identifying a possible source of his infection. The patient had disseminated candidiasis, cytomegalovirus pneumonia, and cryptosporidiosis when he died.

    Original languageEnglish (US)
    Pages (from-to)337-340
    Number of pages4
    JournalAnnals of internal medicine
    Volume99
    Issue number3
    StatePublished - Sep 1 1983

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    Common Variable Immunodeficiency
    Cryptosporidiosis
    Hemophilia A
    Cryptosporidium
    Acquired Immunodeficiency Syndrome
    Helper-Inducer T-Lymphocytes
    Lymphopenia
    Oocysts
    Candidiasis
    Cytomegalovirus
    Bacterial Infections
    Interferon-alpha
    Feces
    Diarrhea
    Pneumonia
    Cats
    Infection
    Serum

    All Science Journal Classification (ASJC) codes

    • Internal Medicine

    Cite this

    Koch, K. L. ; Shankey, T. V. ; Weinstein, G. S. ; Dye, R. E. ; Abt, A. B. ; Current, W. L. ; Eyster, M. Elaine. / Cryptosporidiosis in a patient with hemophilia, common variable hypogammaglobulinemia, and the acquired immunodeficiency syndrome. In: Annals of internal medicine. 1983 ; Vol. 99, No. 3. pp. 337-340.
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    abstract = "A 36-year-old man had chronic, debilitating diarrhea due to cryptosporidiosis. This patient had longstanding common variable hypogammaglobulinemia and recurrent bacterial infections. Immunologic evaluation after discovery of Cryptosporidium showed lymphopenia with persistently reduced numbers of helper/inducer cells (OKT-4), variable numbers of suppressor/cytotoxic cells (OKT-8), OKT-4/OKT-8 ratio of 0.09, and increased levels of serum alpha-interferon, all of which describe the acquired immunodeficiency syndrome. Oocysts of Cryptosporidium were found in feces from the patient's cat, thus identifying a possible source of his infection. The patient had disseminated candidiasis, cytomegalovirus pneumonia, and cryptosporidiosis when he died.",
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    Cryptosporidiosis in a patient with hemophilia, common variable hypogammaglobulinemia, and the acquired immunodeficiency syndrome. / Koch, K. L.; Shankey, T. V.; Weinstein, G. S.; Dye, R. E.; Abt, A. B.; Current, W. L.; Eyster, M. Elaine.

    In: Annals of internal medicine, Vol. 99, No. 3, 01.09.1983, p. 337-340.

    Research output: Contribution to journalArticle

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    AU - Koch, K. L.

    AU - Shankey, T. V.

    AU - Weinstein, G. S.

    AU - Dye, R. E.

    AU - Abt, A. B.

    AU - Current, W. L.

    AU - Eyster, M. Elaine

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    AB - A 36-year-old man had chronic, debilitating diarrhea due to cryptosporidiosis. This patient had longstanding common variable hypogammaglobulinemia and recurrent bacterial infections. Immunologic evaluation after discovery of Cryptosporidium showed lymphopenia with persistently reduced numbers of helper/inducer cells (OKT-4), variable numbers of suppressor/cytotoxic cells (OKT-8), OKT-4/OKT-8 ratio of 0.09, and increased levels of serum alpha-interferon, all of which describe the acquired immunodeficiency syndrome. Oocysts of Cryptosporidium were found in feces from the patient's cat, thus identifying a possible source of his infection. The patient had disseminated candidiasis, cytomegalovirus pneumonia, and cryptosporidiosis when he died.

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