Cryptosporidium parvum - Specific antibody responses among children residing in Milwaukee during the 1993 waterborne outbreak

Alicia C. McDonald, William R. Mac Kenzie, David G. Addiss, Stephen Gradus, George Linke, Elizabeth Zembrowski, Margaret R. Hurd, Michael J. Arrowood, Patrick J. Lammie, Jeffrey W. Priest

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

A major gastroenteritis outbreak among >400,000 residents of Milwaukee, Wisconsin, in April 1993 was attributed to Cryptosporidium parvum oocysts in drinking water. Plasma specimens obtained from children (6 months to 12 years old) for routine blood lead level surveillance March- May 1993 were assayed by ELISA for levels of IgG antibody against the immunodominant Triton-17 and 27-kDa C. parvum antigens. Over a 5-week period, the seroprevalence for antibodies to the 2 antigens increased from 15% to 82% and from 17% to 87%, respectively, in samples from children living in southern ZIP code areas (n = 218), whereas smaller increases (20% to 43% and 22% to 46%, respectively) were noted among samples from children living in northern ZIP code areas (n = 335; P<.0001). The results demonstrate that C. parvum infection was much more widespread than previously appreciated and confirm that infection was associated with residence in the area served by the southern water treatment plant.

Original languageEnglish (US)
Pages (from-to)1373-1379
Number of pages7
JournalJournal of Infectious Diseases
Volume183
Issue number9
DOIs
StatePublished - May 1 2001

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

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