Crystal structure of a yeast TFIIA/TBP/DNA complex

Song Tan, Yvonne Hunziker, David F. Sargent, Timothy J. Richmond

Research output: Contribution to journalArticlepeer-review

249 Scopus citations

Abstract

The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 Å resolution. TFIIA is composed of a P-barrel and a four-helix bundle motif that together have a boot-like appearance. The β-barrel extends the TBP β-sheet and bridges over the DNA major groove immediately upstream of the TATA box. The four-helix bundle contributes substantially to the surface of the complex available for interaction with additional transcription factors.

Original languageEnglish (US)
Pages (from-to)127-134
Number of pages8
JournalNature
Volume381
Issue number6578
DOIs
StatePublished - May 9 1996

All Science Journal Classification (ASJC) codes

  • General

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