Current pharmacologic approaches to treating neuropathic pain

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Most neuropathic analgesic medications have been introduced initially for other medical conditions. Anticonvulsants, local anesthetics, and antidepressants later were found to be effective in the treatment of neuropathic pain. Carbamazepine and the newer anticonvulsants such as gabapentin, lamotrigine, topiramate, and oxcarbazepine are being used as first-line or adjunctive therapy. The newer agents have less potential for drug interactions and a more favorable side-effect profile. Lidocaine administered systemically or topically is useful for some peripheral and central neuropathic pain conditions. The tricyclic antidepressants amitriptyline, nortriptyline, and desipramine have been shown to be effective for the management of neuropathic pain, independent of their antidepressant property. All of the available analgesics have considerable side effects, which necessitate careful titration. Future drug research may focus on developing medications specifically for neuropathic pain. These designer agents may have more desirable action without the unwanted side effects.

Original languageEnglish (US)
Pages (from-to)15-18
Number of pages4
JournalCurrent Pain and Headache Reports
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2004

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Neuralgia
Anticonvulsants
Antidepressive Agents
Analgesics
Nortriptyline
Desipramine
Amitriptyline
Tricyclic Antidepressive Agents
Carbamazepine
Lidocaine
Local Anesthetics
Drug Interactions
Therapeutics
Research
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

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Current pharmacologic approaches to treating neuropathic pain. / Vu, To-Nhu.

In: Current Pain and Headache Reports, Vol. 8, No. 1, 01.01.2004, p. 15-18.

Research output: Contribution to journalArticle

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