Current understanding of the genetic diversity of Mycobacterium avium subsp. paratuberculosis

Alifiya S. Motiwala, Lingling Li, Vivek Kapur, Srinand Sreevatsan

Research output: Contribution to journalShort survey

51 Citations (Scopus)

Abstract

Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Johne's disease (or paratuberculosis). Paratuberculosis is a chronic gastroenteritis mainly affecting cattle, sheep and other ruminants. MAP is also of concern due to the heretofore unresolved issue of its possible role in Crohn's disease in humans. We present here a review of MAP (i) mobile genetic elements; (ii) repetitive elements; (iii) single nucleotide polymorphisms; and (iv) whole-genome comparisons to study the molecular epidemiology of MAP. A summary of the findings to date is presented, and the discriminatory power, advantage and disadvantages of each of the methods are compared and discussed.

Original languageEnglish (US)
Pages (from-to)1406-1418
Number of pages13
JournalMicrobes and Infection
Volume8
Issue number5
DOIs
StatePublished - Apr 1 2006

Fingerprint

Paratuberculosis
Mycobacterium avium
Interspersed Repetitive Sequences
Molecular Epidemiology
Gastroenteritis
Ruminants
Crohn Disease
Single Nucleotide Polymorphism
Sheep
Genome

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

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abstract = "Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Johne's disease (or paratuberculosis). Paratuberculosis is a chronic gastroenteritis mainly affecting cattle, sheep and other ruminants. MAP is also of concern due to the heretofore unresolved issue of its possible role in Crohn's disease in humans. We present here a review of MAP (i) mobile genetic elements; (ii) repetitive elements; (iii) single nucleotide polymorphisms; and (iv) whole-genome comparisons to study the molecular epidemiology of MAP. A summary of the findings to date is presented, and the discriminatory power, advantage and disadvantages of each of the methods are compared and discussed.",
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Current understanding of the genetic diversity of Mycobacterium avium subsp. paratuberculosis. / Motiwala, Alifiya S.; Li, Lingling; Kapur, Vivek; Sreevatsan, Srinand.

In: Microbes and Infection, Vol. 8, No. 5, 01.04.2006, p. 1406-1418.

Research output: Contribution to journalShort survey

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AU - Motiwala, Alifiya S.

AU - Li, Lingling

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AU - Sreevatsan, Srinand

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