Cushing's syndrome due to adrenal adenoma with persistent diurnal cortisol secretory rhythm

Nancy J. Olsen, Victor S. Fang, Leslie J. DeGroot

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

A 41-yr-old female with presumed Cushing's syndrome was found to have a diurnal cortisol rhythm characterized by low values at 8:00 a.m. and consistently high values at 4:00 p.m. and midnight. Hourly sampling of plasma cortisol over 24 hr confirmed this rhythm, as did measurement of urinary free cortisols in samples collected every 6 hr over 24 hr. Hypercortisolemia was not suppressed by 2 mg of dexamethasone given every 6 hr for 24 hr. the adrenal tissue was responsive to ACTH. lodocholesterol scanning revealed unilateral activity, and the patient's syndrome was cured by resection of an adrenal adenoma. In this patient a diurnal cortisol secretory pattern was present due to the secretory activity of the adenoma. The cause of the abnormal but persistent diurnal pattern is unknown.

Original languageEnglish (US)
Pages (from-to)695-700
Number of pages6
JournalMetabolism
Volume27
Issue number6
DOIs
StatePublished - Jun 1978

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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