Cutaneous involvement in multiple myeloma (MM): A case series with clinicopathologic correlation

Jozef Malysz, Giampaolo Talamo, Junjia Zhu, Loren E. Clarke, Michael Bayerl, Liaqat Ali, Klaus Helm, Catherine Chung

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Disease-specific skin lesions are rare in patients with multiple myeloma (MM). Objective We sought to further characterize the clinical and pathologic features of patients with cutaneous involvement with MM. Methods We identified 13 patients with cutaneous lesions of MM. Results Cutaneous lesions consisted of pink, red, and violaceous papules, nodules, and/or plaques that varied in size. Histopathology revealed atypical plasma cells with occasional plasmablastic features. MM had aggressive biologic features and was at an advanced stage in the majority of patients. Despite aggressive management, including chemotherapy and stem-cell transplantation, most patients died of progressive disease within a few months after the development of cutaneous lesions. Limitations The study group was relatively small. Conclusions Cutaneous involvement with MM is associated with aggressive biologic behavior and short survival.

Original languageEnglish (US)
Pages (from-to)878-884
Number of pages7
JournalJournal of the American Academy of Dermatology
Volume74
Issue number5
DOIs
StatePublished - May 1 2016

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Multiple Myeloma
Skin
Stem Cell Transplantation
Plasma Cells
Skin Diseases
Drug Therapy
Survival

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

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title = "Cutaneous involvement in multiple myeloma (MM): A case series with clinicopathologic correlation",
abstract = "Disease-specific skin lesions are rare in patients with multiple myeloma (MM). Objective We sought to further characterize the clinical and pathologic features of patients with cutaneous involvement with MM. Methods We identified 13 patients with cutaneous lesions of MM. Results Cutaneous lesions consisted of pink, red, and violaceous papules, nodules, and/or plaques that varied in size. Histopathology revealed atypical plasma cells with occasional plasmablastic features. MM had aggressive biologic features and was at an advanced stage in the majority of patients. Despite aggressive management, including chemotherapy and stem-cell transplantation, most patients died of progressive disease within a few months after the development of cutaneous lesions. Limitations The study group was relatively small. Conclusions Cutaneous involvement with MM is associated with aggressive biologic behavior and short survival.",
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Cutaneous involvement in multiple myeloma (MM) : A case series with clinicopathologic correlation. / Malysz, Jozef; Talamo, Giampaolo; Zhu, Junjia; Clarke, Loren E.; Bayerl, Michael; Ali, Liaqat; Helm, Klaus; Chung, Catherine.

In: Journal of the American Academy of Dermatology, Vol. 74, No. 5, 01.05.2016, p. 878-884.

Research output: Contribution to journalArticle

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T2 - A case series with clinicopathologic correlation

AU - Malysz, Jozef

AU - Talamo, Giampaolo

AU - Zhu, Junjia

AU - Clarke, Loren E.

AU - Bayerl, Michael

AU - Ali, Liaqat

AU - Helm, Klaus

AU - Chung, Catherine

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AB - Disease-specific skin lesions are rare in patients with multiple myeloma (MM). Objective We sought to further characterize the clinical and pathologic features of patients with cutaneous involvement with MM. Methods We identified 13 patients with cutaneous lesions of MM. Results Cutaneous lesions consisted of pink, red, and violaceous papules, nodules, and/or plaques that varied in size. Histopathology revealed atypical plasma cells with occasional plasmablastic features. MM had aggressive biologic features and was at an advanced stage in the majority of patients. Despite aggressive management, including chemotherapy and stem-cell transplantation, most patients died of progressive disease within a few months after the development of cutaneous lesions. Limitations The study group was relatively small. Conclusions Cutaneous involvement with MM is associated with aggressive biologic behavior and short survival.

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