Cutaneous T cell Lymphoma: an Update on Pathogenesis and Systemic Therapy

Catherine G. Chung, Brian Poligone

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Mycosis fungoides (MF) and its leukemic variant, Sézary syndrome (SS), are malignancies of skin-homing T cells that comprise the majority of cutaneous T cell lymphomas (CTCL). Treatment of CTCL is limited and can be approached by skin-directed therapy or systemic therapy. Recent investigations into the pathogenesis of MF and SS have broadened the therapeutic targets; here, we review emerging concepts in the pathogenesis of MF and SS as well as novel and traditional systemic therapies for MF and SS. These include histone deacetylase inhibitors (vorinostat, romidepsin, panobinostat, and belinostat), monoclonal antibodies (alemtuzumab, brentuximab vedotin, and mogamulizumab) and single-agent cytotoxic chemotherapeutic agents (e.g., pralatrexate, doxorubicin, bendamustine, and forodesine), as well as multi-agent chemotherapy regimens.

Original languageEnglish (US)
Pages (from-to)468-476
Number of pages9
JournalCurrent Hematologic Malignancy Reports
Volume10
Issue number4
DOIs
StatePublished - Dec 1 2015

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

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