Cutting edge: All-trans retinoic acid sustains the stability and function of natural regulatory T cells in an inflammatory milieu

Xiaohui Zhou, Ning Kong, Julie Wang, Huiming Fan, Hejian Zou, David Horwitz, David Brand, Zhongmin Liu, Song Guo Zheng

Research output: Contribution to journalArticlepeer-review

163 Scopus citations

Abstract

Recent studies have demonstrated that plasticity of naturally occurring CD4+Foxp3+ regulatory T cells (nTregs) may account for their inability to control chronic inflammation in established autoimmune diseases. All-trans retinoic acid (atRA), the active derivative of vitamin A, has been demonstrated to promote Foxp3+ Treg differentiation and suppress Th17 development. In this study, we report a vital role of atRA in sustaining the stability and functionality of nTregs in the presence of IL-6.We found that nTregs treated with atRA were resistant to Th17 and other Th cell conversion and maintained Foxp3 expression and suppressive activity in the presence of IL-6 in vitro. atRA decreased IL-6R expression and signaling by nTregs. Of interest, adoptive transfer of nTregs even from arthritic mice treated with atRA suppressed progression of established collagen-induced arthritis. We suggest that nTregs treated with atRA may represent a novel treatment strategy to control established chronic immune-mediated inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)2675-2679
Number of pages5
JournalJournal of Immunology
Volume185
Issue number5
DOIs
StatePublished - Sep 1 2010

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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