Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15

Renu Garg, Ignacio J. Juncadella, Nandhini Ramamoorthi, Ashish, Shobana K. Ananthanarayanan, Venetta Thomas, Mercedes Rincón, Joanna K. Krueger, Erol Fikrig, Christopher M. Yengo, Juan Anguita

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Salp15 is an Ixodes scapularis salivary protein that inhibits CD4 + T cell activation through the repression of TCR ligation-triggered calcium fluxes and IL-2 production. We show in this study that Salp15 binds specifically to the CD4 coreceptor on mammalian host T cells. Salp15 specifically associates through its C-terminal residues with the outermost two extracellular domains of CD4. Upon binding to CD4, Salp15 inhibits the subsequent TCR ligation-induced T cell signaling at the earliest steps including tyrosine phosphorylation of the Src kinase Lck, down-stream effector proteins, and lipid raft reorganization. These results provide a molecular basis to understanding the immunosuppressive activity of Salp15 and its specificity for CD4+ T cells.

Original languageEnglish (US)
Pages (from-to)6579-6583
Number of pages5
JournalJournal of Immunology
Volume177
Issue number10
DOIs
StatePublished - Nov 15 2006

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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