Cutting edge

Rapid in vivo CTL activity by polyoma virus-specific effector and memory CD8+ T cells

Anthony M. Byers, Christopher C. Kemball, Janice M. Moser, Aron Lukacher

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

For viruses that establish persistent infection, continuous immunosurveillance by effector-competent antiviral CD8+ T cells is likely essential for limiting viral replication. Although it is well documented that virus-specific memory CD8+ T cells synthesize cytokines after short term in vitro stimulation, there is limited evidence that these T cells exhibit cytotoxicity, the dominant antiviral effector function. Here, we show that antiviral CD8+ T cells in mice acutely infected by polyoma virus, a persistent mouse pathogen, specifically eliminate viral peptide-pulsed donor spleen cells within minutes after adoptive transfer and do so via a perforin-dependent mechanism. Antiviral memory CD8+ T cells were similarly capable of rapidly mobilizing potent Ag-specific cytotoxic activity in vivo. These findings strongly support the concept that a cytotoxic effector-memory CD8+ T cell population operates in vivo to control this persistent viral infection.

Original languageEnglish (US)
Pages (from-to)17-21
Number of pages5
JournalJournal of Immunology
Volume171
Issue number1
DOIs
StatePublished - Jul 1 2003

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Polyomavirus
T-Lymphocytes
Antiviral Agents
Viruses
Immunologic Monitoring
Perforin
Adoptive Transfer
Virus Diseases
Spleen
Cytokines
Peptides
Infection
Population

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Byers, Anthony M. ; Kemball, Christopher C. ; Moser, Janice M. ; Lukacher, Aron. / Cutting edge : Rapid in vivo CTL activity by polyoma virus-specific effector and memory CD8+ T cells. In: Journal of Immunology. 2003 ; Vol. 171, No. 1. pp. 17-21.
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Cutting edge : Rapid in vivo CTL activity by polyoma virus-specific effector and memory CD8+ T cells. / Byers, Anthony M.; Kemball, Christopher C.; Moser, Janice M.; Lukacher, Aron.

In: Journal of Immunology, Vol. 171, No. 1, 01.07.2003, p. 17-21.

Research output: Contribution to journalArticle

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