Cutting edge: Recombinant adenoviruses induce CD8 T cell responses to an inserted protein whose expression is limited to nonimmune cells

S. A. Prasad, C. C. Norbury, W. Chen, J. R. Bennink, J. W. Yewdell

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

CD8 T cells (TCD8+) play a crucial role in immunity to viruses. Current understanding of activation of naive T cells entails Ag presentation by professional APCs (pAPCs). What happens, however, when viruses evolve to avoid infecting pAPCs? We have studied the consequences of this strategy by generating recombinant adenoviruses that express influenza A virus nucleoprotein under the control of tissue-specific promoters. We show that the immunogenicity of such viruses requires their delivery to organs capable of expressing nucleoprotein. This indicates that infection of pAPCs is not required for adenoviruses to elicit a TCD8+ response, probably due to a cross-priming via pAPCs. While this bodes well for recombinant adenoviruses as vaccines, it dims their prospects as gene therapy vectors.

Original languageEnglish (US)
Pages (from-to)4809-4812
Number of pages4
JournalJournal of Immunology
Volume166
Issue number8
DOIs
StatePublished - Apr 15 2001

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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