Cutting edge: Shift in antigen dependence by an antiviral MHC class Ib-restricted CD8 T cell response during persistent viral infection

Phillip A. Swanson, Amelia R. Hofstetter, Jarad J. Wilson, Aron E. Lukacher

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The requirement for Ag in maintaining memory CD8 T cells often differs between infections that are acutely resolved and those that persist. Using the mouse polyoma virus (PyV) persistent infection model, we recently described a novel CD8 T cell response directed to a PyV peptide presented by Q9, an MHC class Ib molecule. This antiviral Q9-restricted CD8 T cell response is characterized by a 3-mo expansion phase followed by a longterm plateau phase. In this study, we demonstrate that viral Ag is required for this protracted inflation phase but is dispensable for the maintenance of this Q9-restricted CD8 T cell response. Moreover, proliferation by memory T cells, not recruitment of naive PyV-specific T cells, is primarily responsible for Q9-restricted, anti-PyV CD8 T cell inflation. These data reveal a dynamic shift in Ag dependence by an MHC class Ib-restricted memory CD8 T cell response during a persistent viral infection.

Original languageEnglish (US)
Pages (from-to)5198-5202
Number of pages5
JournalJournal of Immunology
Volume182
Issue number9
DOIs
StatePublished - May 1 2009

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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