Cutting Edge: Skin CCR10+ CD8+ T cells support resident regulatory T Cells through the B7.2/Receptor Axis to regulate local immune homeostasis and response

Yaoyao Fu, Jie Yang, Na Xiong

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Resident T cells in barrier tissues are important in protecting against foreign agents but can also contribute to inflammatory diseases if dysregulated. How T cell homeostasis is maintained in barrier tissues is still poorly understood. We report that resident CD8+ T cells directly support maintenance of regulatory T cells (Tregs) in the skin to promote immune homeostasis. Impaired establishment of resident CD8+ T cells caused by knockout of the skin-homing chemokine receptor CCR10 resulted in an altered balance of resident Tregs and CD4+ effector T cells in the skin and overreactive inflammatory responses to cutaneous stimulations. Furthermore, B7.2 expressed on skin CD8+ T cells supports the survival of Tregs, likely through interaction with its receptor CTLA-4, which is highly expressed on skin Tregs. Our findings provide novel insights into T cell homeostatic regulation in the skin and may improve our understanding of the pathobiology of tissue inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)4859-4864
Number of pages6
JournalJournal of Immunology
Volume196
Issue number12
DOIs
StatePublished - Jun 15 2016

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Regulatory T-Lymphocytes
Homeostasis
T-Lymphocytes
Skin
Chemokine Receptors
Cell Survival
Maintenance

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

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title = "Cutting Edge: Skin CCR10+ CD8+ T cells support resident regulatory T Cells through the B7.2/Receptor Axis to regulate local immune homeostasis and response",
abstract = "Resident T cells in barrier tissues are important in protecting against foreign agents but can also contribute to inflammatory diseases if dysregulated. How T cell homeostasis is maintained in barrier tissues is still poorly understood. We report that resident CD8+ T cells directly support maintenance of regulatory T cells (Tregs) in the skin to promote immune homeostasis. Impaired establishment of resident CD8+ T cells caused by knockout of the skin-homing chemokine receptor CCR10 resulted in an altered balance of resident Tregs and CD4+ effector T cells in the skin and overreactive inflammatory responses to cutaneous stimulations. Furthermore, B7.2 expressed on skin CD8+ T cells supports the survival of Tregs, likely through interaction with its receptor CTLA-4, which is highly expressed on skin Tregs. Our findings provide novel insights into T cell homeostatic regulation in the skin and may improve our understanding of the pathobiology of tissue inflammatory diseases.",
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Cutting Edge : Skin CCR10+ CD8+ T cells support resident regulatory T Cells through the B7.2/Receptor Axis to regulate local immune homeostasis and response. / Fu, Yaoyao; Yang, Jie; Xiong, Na.

In: Journal of Immunology, Vol. 196, No. 12, 15.06.2016, p. 4859-4864.

Research output: Contribution to journalArticle

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AB - Resident T cells in barrier tissues are important in protecting against foreign agents but can also contribute to inflammatory diseases if dysregulated. How T cell homeostasis is maintained in barrier tissues is still poorly understood. We report that resident CD8+ T cells directly support maintenance of regulatory T cells (Tregs) in the skin to promote immune homeostasis. Impaired establishment of resident CD8+ T cells caused by knockout of the skin-homing chemokine receptor CCR10 resulted in an altered balance of resident Tregs and CD4+ effector T cells in the skin and overreactive inflammatory responses to cutaneous stimulations. Furthermore, B7.2 expressed on skin CD8+ T cells supports the survival of Tregs, likely through interaction with its receptor CTLA-4, which is highly expressed on skin Tregs. Our findings provide novel insights into T cell homeostatic regulation in the skin and may improve our understanding of the pathobiology of tissue inflammatory diseases.

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