Cutting Edge: Skin CCR10+ CD8+ T cells support resident regulatory T Cells through the B7.2/Receptor Axis to regulate local immune homeostasis and response

Yaoyao Fu, Jie Yang, Na Xiong

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Resident T cells in barrier tissues are important in protecting against foreign agents but can also contribute to inflammatory diseases if dysregulated. How T cell homeostasis is maintained in barrier tissues is still poorly understood. We report that resident CD8+ T cells directly support maintenance of regulatory T cells (Tregs) in the skin to promote immune homeostasis. Impaired establishment of resident CD8+ T cells caused by knockout of the skin-homing chemokine receptor CCR10 resulted in an altered balance of resident Tregs and CD4+ effector T cells in the skin and overreactive inflammatory responses to cutaneous stimulations. Furthermore, B7.2 expressed on skin CD8+ T cells supports the survival of Tregs, likely through interaction with its receptor CTLA-4, which is highly expressed on skin Tregs. Our findings provide novel insights into T cell homeostatic regulation in the skin and may improve our understanding of the pathobiology of tissue inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)4859-4864
Number of pages6
JournalJournal of Immunology
Volume196
Issue number12
DOIs
StatePublished - Jun 15 2016

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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