Cutting edge: STAT6 Signaling in eosinophils is necessary for development of allergic airway inflammation

Kindra Stokes, Nelson M. LaMarche, Nasif Islam, Amie Wood, Weishan Huang, Avery August

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Eosinophils are critical cellular mediators in allergic asthma and inflammation; however, the signals that regulate their functions are unclear. The transcription factor STAT6 regulates Th2 cytokine responses, acting downstream of IL-4 and IL-13. We showed previously that eosinophil-derived IL-13 plays an important role in the recruitment of T cells to the lung and the subsequent development of allergic asthma. However, whether eosinophils respond to Th2 signals to control allergic airway inflammation is unclear. In this report, we show that STAT6-/- eosinophils are unable to induce the development of allergic lung inflammation, including recruitment of CD4+ T cells, mucus production, and development of airways hyperresponsiveness. This is likely due to the reduced migration of STAT6-/- eosinophils to the lung and in response to eotaxin. These data indicate that, like Th cells, eosinophils need to respond to Th2 cytokines via STAT6 during the development of allergic airway inflammation.

Original languageEnglish (US)
Pages (from-to)2477-2481
Number of pages5
JournalJournal of Immunology
Volume194
Issue number6
DOIs
StatePublished - Mar 15 2015

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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