Cystic pancreatic tumors (CPT): Predictors of malignant behavior

Milind Javle, Pankaj Shah, Jihnhee Yu, Vishal Bhagat, Alan Litwin, Renuka Iyer, John Gibbs

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Background and Objectives: Due to widespread use of imaging studies, increasing cystic pancreatic tumor (CPT) cases are being detected. The diagnosis of malignancy in CPT cases requires pancreatectomy. Clinical and laboratory characteristics of CPT may predict underlying malignancy. Methods: CPT cases treated between 1994 and 2004 at our institution were included. Pseudocysts were excluded. Serous cystadenoma (SCA), mucinous cystadenoma (MCA), intrapapillary mucinous tumor, cystic endocrine tumor, and lymphoepithelial cysts were classified as benign or pre-malignant. Serous cystadenocarcinoma (SCACA), mucinous cystadenocarcinoma (MCACA), and adenocarcinoma (ACA) were classified as malignant. Results: Thirty-five patients had histological confirmation. Median age was 65 years. Male/female ratio was higher in malignant group (P = 0.0284). Weight loss and abdominal mass were more prevalent in malignant group (P = 0.042 and 0.028, respectively). Malignant lesions were larger, associated with local invasion (superior mesenteric artery (SMA), superior mesenteric vein (SMV), portal vein (PV) complex or celiac encasement) and CA 19-9 elevation. On univariate analyses, local invasion (P = 0.0029), negative surgical intervention (P = 0.0010), presence of ACA (P = 0.0044), or malignant CPT (P = 0.0018) were associated with shorter survival. On a multivariate analysis, local invasion was associated with shorter survival [Hazard ratio (HR) = 4.322, P = 0.0218], while surgical intervention was associated with improved survival (HR = 0.179, P = 0.0124). Conclusion: Male sex, abdominal mass, weight loss, larger tumor size, local invasion, and elevated CA 19-9 were associated with malignant CPT.

Original languageEnglish (US)
Pages (from-to)221-228
Number of pages8
JournalJournal of Surgical Oncology
Volume95
Issue number3
DOIs
StatePublished - Mar 1 2007

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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    Javle, M., Shah, P., Yu, J., Bhagat, V., Litwin, A., Iyer, R., & Gibbs, J. (2007). Cystic pancreatic tumors (CPT): Predictors of malignant behavior. Journal of Surgical Oncology, 95(3), 221-228. https://doi.org/10.1002/jso.20648