Cytogenetics in hereditary malignant melanoma and dysplastic nevus syndrome: Is dysplastic nevus syndrome a chromosome instability disorder?

Neil Caporaso, Mark H. Greene, Shein Tsai, Linda Williams Pickle, John J. Mulvihill

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Analysis of peripheral blood lymphocyte Giemsa-banded karyotypes was performed on 163 family members from 13 melanoma-prone families. Patients were classified regarding the presence of cutaneous melanoma and dysplastic nevi (a well characterized melanoma precursor), and each karyotype was scored for the number of cells containing the following: major structural, minor structural, and numerical abnormalities. No clonal cytogenetic abnormalities were observed. Cutaneous malignant melanoma and dysplastic nevi syndrome patients each had increased abnormalities of all types combined, compared with pooled controls (i.e., normal family members, and spouses; respectively, χ2 = 6.02, p = 0.01; χ2 = 5.29, p = 0.02). There was a statistically significant p-value for major structural abnormalities for melanoma patients and numerical abnormalities for the dysplastic nevi patients. Minor structural abnormalities did not differ in any of the groups. In addition, studies of ultraviolet induced sister chromatid exchange, in vitro tetraploidy, and extended prophase banding were performed on a limited number of patients. No significant differences between cases and controls were observed in these tests. Our data suggest that a chromosome instability abnormality may contribute to the pathogenesis of hereditary melanoma.

Original languageEnglish (US)
Pages (from-to)299-314
Number of pages16
JournalCancer Genetics and Cytogenetics
Volume24
Issue number2
DOIs
StatePublished - Jan 1 1987

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Chromosome Disorders
Dysplastic Nevus Syndrome
Chromosomal Instability
Cytogenetics
Melanoma
Karyotype
Chromosome Aberrations
Prophase
Sister Chromatid Exchange
Tetraploidy
Spouses
Cell Count
Lymphocytes
Skin

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Caporaso, Neil ; Greene, Mark H. ; Tsai, Shein ; Pickle, Linda Williams ; Mulvihill, John J. / Cytogenetics in hereditary malignant melanoma and dysplastic nevus syndrome : Is dysplastic nevus syndrome a chromosome instability disorder?. In: Cancer Genetics and Cytogenetics. 1987 ; Vol. 24, No. 2. pp. 299-314.
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Cytogenetics in hereditary malignant melanoma and dysplastic nevus syndrome : Is dysplastic nevus syndrome a chromosome instability disorder? / Caporaso, Neil; Greene, Mark H.; Tsai, Shein; Pickle, Linda Williams; Mulvihill, John J.

In: Cancer Genetics and Cytogenetics, Vol. 24, No. 2, 01.01.1987, p. 299-314.

Research output: Contribution to journalArticle

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