Cytomegalovirus colitis and viremia from mycophenolate mofetil monotherapy in birdshot chorioretinopathy

Seth M. Pantanelli, Yousuf M. Khalifa

Research output: Contribution to journalArticle

Abstract

Purpose: To describe a case of cytomegalovirus (CMV) viremia and colitis in a patient on mycophenolate mofetil (MMF) monotherapy for birdshot chorioretinopathy. Design: Case report. Methods: Retrospective chart review. Results: Treatment with MMF 1.5g twice daily for 5 years led to leucopenia and a CD4 count of 299, which resulted in active CMV infection. Conclusions: Treatment with MMF alone may put otherwise immune-competent individuals at risk for opportunistic CMV infection. Greater awareness of this association may allow for better monitoring, earlier detection, and treatment of future cases.

Original languageEnglish (US)
Pages (from-to)450-452
Number of pages3
JournalOcular Immunology and Inflammation
Volume19
Issue number6
DOIs
StatePublished - Dec 1 2011

Fingerprint

Mycophenolic Acid
Viremia
Colitis
Cytomegalovirus
Cytomegalovirus Infections
Opportunistic Infections
Leukopenia
CD4 Lymphocyte Count
Therapeutics
Birdshot chorioretinopathy

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Ophthalmology

Cite this

@article{7dae67f99e8a40bcb2b462cc479eef6c,
title = "Cytomegalovirus colitis and viremia from mycophenolate mofetil monotherapy in birdshot chorioretinopathy",
abstract = "Purpose: To describe a case of cytomegalovirus (CMV) viremia and colitis in a patient on mycophenolate mofetil (MMF) monotherapy for birdshot chorioretinopathy. Design: Case report. Methods: Retrospective chart review. Results: Treatment with MMF 1.5g twice daily for 5 years led to leucopenia and a CD4 count of 299, which resulted in active CMV infection. Conclusions: Treatment with MMF alone may put otherwise immune-competent individuals at risk for opportunistic CMV infection. Greater awareness of this association may allow for better monitoring, earlier detection, and treatment of future cases.",
author = "Pantanelli, {Seth M.} and Khalifa, {Yousuf M.}",
year = "2011",
month = "12",
day = "1",
doi = "10.3109/09273948.2011.611961",
language = "English (US)",
volume = "19",
pages = "450--452",
journal = "Ocular Immunology and Inflammation",
issn = "0927-3948",
publisher = "Informa Healthcare",
number = "6",

}

Cytomegalovirus colitis and viremia from mycophenolate mofetil monotherapy in birdshot chorioretinopathy. / Pantanelli, Seth M.; Khalifa, Yousuf M.

In: Ocular Immunology and Inflammation, Vol. 19, No. 6, 01.12.2011, p. 450-452.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cytomegalovirus colitis and viremia from mycophenolate mofetil monotherapy in birdshot chorioretinopathy

AU - Pantanelli, Seth M.

AU - Khalifa, Yousuf M.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Purpose: To describe a case of cytomegalovirus (CMV) viremia and colitis in a patient on mycophenolate mofetil (MMF) monotherapy for birdshot chorioretinopathy. Design: Case report. Methods: Retrospective chart review. Results: Treatment with MMF 1.5g twice daily for 5 years led to leucopenia and a CD4 count of 299, which resulted in active CMV infection. Conclusions: Treatment with MMF alone may put otherwise immune-competent individuals at risk for opportunistic CMV infection. Greater awareness of this association may allow for better monitoring, earlier detection, and treatment of future cases.

AB - Purpose: To describe a case of cytomegalovirus (CMV) viremia and colitis in a patient on mycophenolate mofetil (MMF) monotherapy for birdshot chorioretinopathy. Design: Case report. Methods: Retrospective chart review. Results: Treatment with MMF 1.5g twice daily for 5 years led to leucopenia and a CD4 count of 299, which resulted in active CMV infection. Conclusions: Treatment with MMF alone may put otherwise immune-competent individuals at risk for opportunistic CMV infection. Greater awareness of this association may allow for better monitoring, earlier detection, and treatment of future cases.

UR - http://www.scopus.com/inward/record.url?scp=81855224892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81855224892&partnerID=8YFLogxK

U2 - 10.3109/09273948.2011.611961

DO - 10.3109/09273948.2011.611961

M3 - Article

C2 - 22106917

AN - SCOPUS:81855224892

VL - 19

SP - 450

EP - 452

JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

SN - 0927-3948

IS - 6

ER -