Cytoplasmic rheology of passive neutrophils

Cheng Dong, R. Skalak, K. L.P. Sung

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

The rheological properties of leukocytes are important to their effectiveness in the microcirculation. Previous studies based on in vitro data from micropipette experiments suggest that a Maxwell fluid bounded by a cortical shell with persistent tension is a realistic model for non-activated neutrophils in both the rapid and slow deformation phases. However, various viscoelastic coefficients have been obtained depending on the degree of cell deformation. In the present paper it is demonstrated that the cytoplasmic apparent viscosity and elasticity vary continuously, depending on the degree of deformation. These apparent variations are due to the inhomogeneous nature of the neutrophil internal structure. It is shown that the nucleus is much stiffer than the cytoplasm. The composite structure of the cell results in the deformation-dependent properties.

Original languageEnglish (US)
Pages (from-to)557-567
Number of pages11
JournalBiorheology
Volume28
Issue number6
DOIs
StatePublished - Jan 1 1991

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Rheology
Neutrophils
Elasticity
Microcirculation
Viscosity
Cytoplasm
Leukocytes
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Dong, Cheng ; Skalak, R. ; Sung, K. L.P. / Cytoplasmic rheology of passive neutrophils. In: Biorheology. 1991 ; Vol. 28, No. 6. pp. 557-567.
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Cytoplasmic rheology of passive neutrophils. / Dong, Cheng; Skalak, R.; Sung, K. L.P.

In: Biorheology, Vol. 28, No. 6, 01.01.1991, p. 557-567.

Research output: Contribution to journalArticle

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