Cytosolic calcium oscillations in submandibular gland cells

Li Su, Chun Yan Ma, Yandong Zhou, Yan Hong Jia, Zong Jie Cui

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Calcium oscillations can, by default, encode diverse and specific signals by different modes of modulation. Frequency modulation is illustrated by the activation of calcium/calmodulin-dependent protein kinase II at unit Hz, and of calcineurin at 10 mHz frequencies, respectively. The submandibular gland secretory axis is characterized by both potassium and osmolarity gradients from the luminal side of the secretory cells. Such gradients may play significant physiological roles through the feedback modulation of cholinergic stimulation. High potassium transforms plateau calcium increases induced by cholinergic stimulation of the submandibular acinar cells into oscillatory calcium increases. The ductal cells may have similar mechanisms of feedback modulation both by high potassium and by hypoosmolarity. Such feedback mechanisms could modulate the decision-making process for determining which secretory products are selectively released after nerve stimulation.

Original languageEnglish (US)
Pages (from-to)843-847
Number of pages5
JournalActa Pharmacologica Sinica
Volume27
Issue number7
DOIs
StatePublished - Jul 1 2006

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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