Cytotoxic T-cell response to H-Y antigen by B6.C-H-2(bm12) and B10.BR mice

A. Juretic, E. Juretic, Z. A. Nagy, J. Klein

Research output: Contribution to journalArticle

Abstract

Cytotoxic T-cell response to the male-specific histocompatibility antigen (H-Y) is often used as an experimental model for studying the genetic control of the immune response. This anti-H-Y response is shown to be a complex one, with multicellular interactions involving genes of the H-2 complex, and also some genes unlinked to H-2. For the analysis of the genetic control of the anti-H-Y immune response, different inbred strains have been used and classified accordingly as responders or non-responders. During the authors' studies of the genetic control of the immune response, some of the strains described as non-responders were found to behave as responders, namely strains B6.C-H-2(bm12) and B10.BR. This finding has added to the intricacy of current data on the genetic control of immune response to H-Y antigen.

Original languageEnglish (US)
Pages (from-to)671-675
Number of pages5
JournalImmunology
Volume55
Issue number4
StatePublished - Jan 1 1985

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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    Juretic, A., Juretic, E., Nagy, Z. A., & Klein, J. (1985). Cytotoxic T-cell response to H-Y antigen by B6.C-H-2(bm12) and B10.BR mice. Immunology, 55(4), 671-675.