Daily variation of particulate air pollution and poor cardiac autonomic control in the elderly

Duanping Liao, John Creason, Carl Shy, Ron Williams, Randall Watts, Roy Zweidinger

Research output: Contribution to journalArticle

357 Citations (Scopus)

Abstract

Particulate matter air pollution (PM) has been related to cardiovascular disease mortality in a number of recent studies. The pathophysiologic mechanisms for this association are under study. Low heart rate variability, a marker of poor cardiac autonomic control, is associated with higher risk of myocardial infarction and sudden cardiac death. To address the possible mechanisms for PM-cardiovascular disease mortality we examined the cardiac autonomic response to daily variations in PM in 26 elderly (mean age 81) individuals for 3 consecutive weeks. Several standardized methods were used to measure 24-hr average PM concentrations prior to the clinical test inside (indoor PM2.5) and immediately outside (outdoor PM2.5 and PM2.5-10) of participants' residences. Resting, supine, 6-min R wave to R wave (R-R) interval data were collected to estimate high frequency (0.15-0.40 Hz) and low frequency (0.04-0.15 Hz) powers and standard deviation of normal R-R intervals (SDNN) as cardiac autonomic control indices. Participant-specific lower heart rate variability days were defined as days for which the high-frequency indices fell below the first tertile of the individual's high-frequency distribution over the study period. Indoor PM2.5 > 15 μg/m3 was used to define high pollution days. Results show that the odds ratio (95% confidence interval) of low heart rate variability high frequency for high (vs. not high) pollution days was 3.08 (1.43, 6.59). The β-coefficients (standard error) from mixed models to assess the quantitative relationship between variations in indoor PM2.5 and the log-transformed high frequency, low frequency, and SDNN were: -0.029 (0.010), -0.027 (0.009), and -0.004 (0.003), respectively. This first study of cardiac autonomic control response to daily variations of PM2.5 indicates that increased levels of PM2.5 are associated with lower cardiac autonomic control, suggesting a possible mechanistic link between PM and cardiovascular disease mortality.

Original languageEnglish (US)
Pages (from-to)521-525
Number of pages5
JournalEnvironmental health perspectives
Volume107
Issue number7
DOIs
StatePublished - Jan 1 1999

Fingerprint

Air Pollution
Cardiovascular Diseases
Heart Rate
Mortality
Particulate Matter
Sudden Cardiac Death
Odds Ratio
Myocardial Infarction
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Liao, Duanping ; Creason, John ; Shy, Carl ; Williams, Ron ; Watts, Randall ; Zweidinger, Roy. / Daily variation of particulate air pollution and poor cardiac autonomic control in the elderly. In: Environmental health perspectives. 1999 ; Vol. 107, No. 7. pp. 521-525.
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Daily variation of particulate air pollution and poor cardiac autonomic control in the elderly. / Liao, Duanping; Creason, John; Shy, Carl; Williams, Ron; Watts, Randall; Zweidinger, Roy.

In: Environmental health perspectives, Vol. 107, No. 7, 01.01.1999, p. 521-525.

Research output: Contribution to journalArticle

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