TY - JOUR
T1 - Dairy Foods and Dairy Fats
T2 - New Perspectives on Pathways Implicated in Cardiometabolic Health
AU - Hirahatake, Kristin M.
AU - Bruno, Richard S.
AU - Bolling, Bradley W.
AU - Blesso, Christopher
AU - Alexander, Lacy M.
AU - Adams, Sean H.
N1 - Funding Information:
SHA’s research is funded in part by USDA-Agricultural Research Project 6026-51000-010-05S. Support for RSB is provided by USDA-NIFA 2019-67017-29259, the Ohio Agricultural Research and Development Center at the Ohio State University, and the National Dairy Council. BWB’s research is funded in part by the National Dairy Council. Author disclosures: SHA has received honoraria from ILSI North America, the National Dairy Council (NDC), the National Cattlemen’s Beef Association, Herbalife, and the Council for Responsible Nutrition as a presenter and participant at sponsored scientific conferences. RSB has received honoraria from NDC to serve as an external research advisor and from Abbott Nutrition for serving as a presenter at a sponsored scientific conference. BWB has received honoraria from NDC and Nederlanse Zuivel Oranisatie for presenting research at scientific conferences. CB has received honoraria from NDC and the America Egg Board as a presenter and participant at sponsored scientific conferences. LMA has received funding from NDC, NHLBI, and Performance Health. KMH has received funding from NDC to coordinate author contributions and to write the article. The National Dairy Council (NDC) sponsored the 2018 Scientific Summit: A New Look at Dairy Foods and Healthy Eating Patterns. The sponsor reviewed this manuscript prior to submission. All editorial decisions were solely left to the authors, and this report reflects the independent opinions and views of the authors. Address correspondence to SHA (e-mail: shadams@uams.edu). Abbreviations used: ACE, angiotensin-converting enzyme; ADMA, asymmetric dimethylarginine; AhR, aryl hydrocarbon receptor; ALT, alanine transaminase; AST, aspartate transaminase; CRP, C-reactive protein; CVD, cardiovascular disease; DASH, Dietary Approaches to Stop Hypertension; DGA, Dietary Guidelines for Americans; FMD, flow-mediated dilation; GI, gastrointestinal; GLP-1, glucagon-like peptide-1; HFHC, high-fat, high calorie; HFM, high-fat meal; hsCRP, high-sensitivity CRP; LBP, LPS-binding protein; MFGM, milk fat globule membrane; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; NFDM, nonfat dry milk; PBMC, peripheral blood mononuclear cell; SDMA, symmetric dimethylarginine; SM, sphingomyelin; T2D, type 2 diabetes; TLR4, Toll-like receptor 4.
Publisher Copyright:
© American Society for Nutrition 2019.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Low-fat and nonfat dairy products have been promoted as part of a healthy dietary pattern by both US dietary guidelines and professional organizations for several decades. The basis for this recommendation stems in part from the putative negative cardiometabolic effects associated with saturated fat consumption. However, as nutrition research has shifted from a single nutrient to a whole-food/dietary pattern approach, the role of dairy foods and dairy fat in the diet-disease relationship is being reexamined. Most observational and experimental evidence does not support a detrimental relationship between full-fat dairy intake and cardiometabolic health, including risks of cardiovascular disease and type 2 diabetes. Indeed, an expanded understanding of the dairy food matrix and the bioactive properties of dairy fats and other constituents suggests a neutral or potentially beneficial role in cardiometabolic health. To consider how consuming dairy foods, including full-fat dairy, is associated with cardiometabolic health, this review provides an innovative perspective on mechanisms that link dairy consumption to 3 main biological systems at the core of metabolic health, the gastrointestinal, hepatic, and vascular systems.
AB - Low-fat and nonfat dairy products have been promoted as part of a healthy dietary pattern by both US dietary guidelines and professional organizations for several decades. The basis for this recommendation stems in part from the putative negative cardiometabolic effects associated with saturated fat consumption. However, as nutrition research has shifted from a single nutrient to a whole-food/dietary pattern approach, the role of dairy foods and dairy fat in the diet-disease relationship is being reexamined. Most observational and experimental evidence does not support a detrimental relationship between full-fat dairy intake and cardiometabolic health, including risks of cardiovascular disease and type 2 diabetes. Indeed, an expanded understanding of the dairy food matrix and the bioactive properties of dairy fats and other constituents suggests a neutral or potentially beneficial role in cardiometabolic health. To consider how consuming dairy foods, including full-fat dairy, is associated with cardiometabolic health, this review provides an innovative perspective on mechanisms that link dairy consumption to 3 main biological systems at the core of metabolic health, the gastrointestinal, hepatic, and vascular systems.
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U2 - 10.1093/advances/nmz105
DO - 10.1093/advances/nmz105
M3 - Review article
C2 - 31555799
AN - SCOPUS:85081941378
SN - 2161-8313
VL - 11
SP - 266
EP - 279
JO - Advances in nutrition (Bethesda, Md.)
JF - Advances in nutrition (Bethesda, Md.)
IS - 2
ER -