TY - JOUR
T1 - DAP-2, the Drosophila homolog of transcription factor AP-2
AU - Monge, Ignacio
AU - Mitchell, Pamela J.
N1 - Funding Information:
We thank Markus Noll and Joy Alcedo for kindly providing Drosophila cDNA libraries and staged embryo cDNA; Heinrich Reichert, Barry Dickson, Ernst Hafen, Markus Noll, Markus Affolter, Joy Alcedo, Doris Brentrup, Thomas Gutjahr, and Lei Xue for stimulating discussions and advice; and Eric Kubli for fly-culture space. This work was funded by the Swiss National Science Foundation (31-47228.96), Sandoz-Stiftung, and the Roche Research Foundation.
PY - 1998/8
Y1 - 1998/8
N2 - Transcription factor AP-2 is essential for craniofacial, nervous system, and limb development in the mouse. We report here the cloning and expression pattern analysis of DAP-2, the Drosophila homolog of AP-2 family genes. DAP- 2 is expressed in discrete regions of procephalic neuroectoderm, the brain ventral nerve cord, and maxillary segment during Drosophila embryogenesis, and in the brain, optic-lobes, ventral nerve cord, antenno-maxillary complex, and antennal and leg imaginal disks in third instar larvae. Protein sequence conservation and parallels between the embryonic expression patterns of DAP- 2 and mammalian AP-2 family genes indicate that transcription factor AP-2 has been structurally and functionally conserved during metazoan evolution.
AB - Transcription factor AP-2 is essential for craniofacial, nervous system, and limb development in the mouse. We report here the cloning and expression pattern analysis of DAP-2, the Drosophila homolog of AP-2 family genes. DAP- 2 is expressed in discrete regions of procephalic neuroectoderm, the brain ventral nerve cord, and maxillary segment during Drosophila embryogenesis, and in the brain, optic-lobes, ventral nerve cord, antenno-maxillary complex, and antennal and leg imaginal disks in third instar larvae. Protein sequence conservation and parallels between the embryonic expression patterns of DAP- 2 and mammalian AP-2 family genes indicate that transcription factor AP-2 has been structurally and functionally conserved during metazoan evolution.
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U2 - 10.1016/S0925-4773(98)00125-7
DO - 10.1016/S0925-4773(98)00125-7
M3 - Article
C2 - 9867351
AN - SCOPUS:0032143085
SN - 2667-291X
VL - 76
SP - 191
EP - 195
JO - Cells and Development
JF - Cells and Development
IS - 1-2
ER -