Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background

Vishal Singh, Beng San Yeoh, Marit Nilsen-Hamilton, Thorsten Berger, Tak W. Mak, Matam Vijay Kumar

Research output: Contribution to journalArticle

Abstract

The data herein is related to the research article entitled “Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis” (Singh et al., 2016) [1] where we have demonstrated that C57BL/6 Lipocalin 2 deficient mice (Lcn2KO) developed chronic colitis upon anti-interleukin-10 receptor (αIL-10R) monoclonal antibody administration. In the present article, we evaluated the susceptibility of BALB/c Lcn2KO mice and their WT littermates to the αIL-10R neutralization-induced chronic colitis. Our data showed that αIL-10R mAb-treated BALB/c Lcn2KO mice exhibited severe chronic colitis (i.e., splenomegaly, colomegaly, colonic pathology, and incidence of rectal prolapse) when compared to WT mice.

Original languageEnglish (US)
Pages (from-to)588-592
Number of pages5
JournalData in Brief
Volume11
DOIs
StatePublished - Apr 1 2017

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Interleukin-10 Receptors
Colitis
Rectal Prolapse
Siderophores
Microbiota
Splenomegaly
Carrier Proteins
Homeostasis
Monoclonal Antibodies
Pathology
Lipocalin-2
Incidence
Research

All Science Journal Classification (ASJC) codes

  • General

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Singh, Vishal ; Yeoh, Beng San ; Nilsen-Hamilton, Marit ; Berger, Thorsten ; Mak, Tak W. ; Kumar, Matam Vijay. / Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background. In: Data in Brief. 2017 ; Vol. 11. pp. 588-592.
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Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background. / Singh, Vishal; Yeoh, Beng San; Nilsen-Hamilton, Marit; Berger, Thorsten; Mak, Tak W.; Kumar, Matam Vijay.

In: Data in Brief, Vol. 11, 01.04.2017, p. 588-592.

Research output: Contribution to journalArticle

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AU - Mak, Tak W.

AU - Kumar, Matam Vijay

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AB - The data herein is related to the research article entitled “Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis” (Singh et al., 2016) [1] where we have demonstrated that C57BL/6 Lipocalin 2 deficient mice (Lcn2KO) developed chronic colitis upon anti-interleukin-10 receptor (αIL-10R) monoclonal antibody administration. In the present article, we evaluated the susceptibility of BALB/c Lcn2KO mice and their WT littermates to the αIL-10R neutralization-induced chronic colitis. Our data showed that αIL-10R mAb-treated BALB/c Lcn2KO mice exhibited severe chronic colitis (i.e., splenomegaly, colomegaly, colonic pathology, and incidence of rectal prolapse) when compared to WT mice.

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