Data on importance of hematopoietic cell derived Lipocalin 2 against gut inflammation

Piu Saha, Vishal Singh, Xia Xiao, Beng San Yeoh, Matam Vijay-Kumar

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The data herein is related to the research article entitled "Microbiota-inducible innate immune siderophore binding protein Lipocalin 2 is critical for intestinal homeostasis" (Singh et al., 2016) [1]. In the present article, we monitored dextran sodium sulfate (DSS)-induced colitis development upon Lipocalin 2 (Lcn2) neutralization, and examined the survival of Lcn2 deficient (Lcn2KO) mice and their WT littermates upon DSS challenge. To dissect the relative contribution of immune and non-immune cells-derived Lcn2 in mediating protection against gut inflammation, we generated respective bone marrow chimera and evaluated their susceptibility to IL-10 receptor neutralization-induced chronic colitis.Neutralization of Lcn2 in WT mice resulted in exacerbated DSS-induced colitis. Notably, mice lacking Lcn2 exhibited 100% mortality whereas only 20% mortality was observed in WT mice upon DSS challenge. Further, data from bone marrow chimera showed that immune cell-derived Lcn2 is the major contributor in conferring protection against colitis.

Original languageEnglish (US)
Pages (from-to)812-816
Number of pages5
JournalData in Brief
Volume8
DOIs
StatePublished - Sep 1 2016

All Science Journal Classification (ASJC) codes

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