Data on importance of hematopoietic cell derived Lipocalin 2 against gut inflammation

Piu Saha, Vishal Singh, Xia Xiao, Beng San Yeoh, Matam Vijay Kumar

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The data herein is related to the research article entitled "Microbiota-inducible innate immune siderophore binding protein Lipocalin 2 is critical for intestinal homeostasis" (Singh et al., 2016) [1]. In the present article, we monitored dextran sodium sulfate (DSS)-induced colitis development upon Lipocalin 2 (Lcn2) neutralization, and examined the survival of Lcn2 deficient (Lcn2KO) mice and their WT littermates upon DSS challenge. To dissect the relative contribution of immune and non-immune cells-derived Lcn2 in mediating protection against gut inflammation, we generated respective bone marrow chimera and evaluated their susceptibility to IL-10 receptor neutralization-induced chronic colitis.Neutralization of Lcn2 in WT mice resulted in exacerbated DSS-induced colitis. Notably, mice lacking Lcn2 exhibited 100% mortality whereas only 20% mortality was observed in WT mice upon DSS challenge. Further, data from bone marrow chimera showed that immune cell-derived Lcn2 is the major contributor in conferring protection against colitis.

Original languageEnglish (US)
Pages (from-to)812-816
Number of pages5
JournalData in Brief
Volume8
DOIs
StatePublished - Sep 1 2016

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Dextran Sulfate
Inflammation
Colitis
Interleukin-10 Receptors
Bone Marrow
Siderophores
Mortality
Microbiota
Lipocalin-2
Carrier Proteins
Homeostasis
Research

All Science Journal Classification (ASJC) codes

  • General

Cite this

Saha, Piu ; Singh, Vishal ; Xiao, Xia ; Yeoh, Beng San ; Kumar, Matam Vijay. / Data on importance of hematopoietic cell derived Lipocalin 2 against gut inflammation. In: Data in Brief. 2016 ; Vol. 8. pp. 812-816.
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Data on importance of hematopoietic cell derived Lipocalin 2 against gut inflammation. / Saha, Piu; Singh, Vishal; Xiao, Xia; Yeoh, Beng San; Kumar, Matam Vijay.

In: Data in Brief, Vol. 8, 01.09.2016, p. 812-816.

Research output: Contribution to journalArticle

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AU - Saha, Piu

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AU - Xiao, Xia

AU - Yeoh, Beng San

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AB - The data herein is related to the research article entitled "Microbiota-inducible innate immune siderophore binding protein Lipocalin 2 is critical for intestinal homeostasis" (Singh et al., 2016) [1]. In the present article, we monitored dextran sodium sulfate (DSS)-induced colitis development upon Lipocalin 2 (Lcn2) neutralization, and examined the survival of Lcn2 deficient (Lcn2KO) mice and their WT littermates upon DSS challenge. To dissect the relative contribution of immune and non-immune cells-derived Lcn2 in mediating protection against gut inflammation, we generated respective bone marrow chimera and evaluated their susceptibility to IL-10 receptor neutralization-induced chronic colitis.Neutralization of Lcn2 in WT mice resulted in exacerbated DSS-induced colitis. Notably, mice lacking Lcn2 exhibited 100% mortality whereas only 20% mortality was observed in WT mice upon DSS challenge. Further, data from bone marrow chimera showed that immune cell-derived Lcn2 is the major contributor in conferring protection against colitis.

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