DC homeostasis in hematopoietic stem cell transplantation

Matthew P. Collin, M. Bogunovic, M. Merad

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Hematopoietic stem cell transplantation is an important experimental tool and therapeutic modality. Its efficacy and toxicity are both linked to a GvH reaction that is initiated by donor T cells recognizing recipient APC, of which DC are the most potent. In most tissues recipient DC are replaced after transplantation because they turnover rapidly from BM-derived precursors. However, in a number of sites, notably the skin, recipient DC may persist and even self-renew for many months after transplantation. Understanding the homeostasis of different APC populations and how they are related to the induction of alloreactivity may help to improve the therapeutic benefit of transplantation.

Original languageEnglish (US)
Pages (from-to)521-531
Number of pages11
JournalCytotherapy
Volume9
Issue number6
DOIs
StatePublished - 2007

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Genetics(clinical)
  • Cell Biology
  • Cancer Research
  • Transplantation

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