Some aspects of multidecadal Atlantic climate variability, and its impact on regional and hemispheric scale climate, are reviewed. Observational analyses have documented distinct patterns of Atlantic variability with decadal (8-12 years) and multidecadal (30-80 years) time scales. Numerical models have succeeded in capturing some aspects of this observed variability, but much work remains to understand the mechanisms of the observed variability. The impacts of the variability-particularly on the multidecadal time scale-are striking, including modulation of African and Indian summer monsoon rainfall, summer climate over North America and Europe, and a potential influence on Atlantic hurricane activity. Some of the observed variability, particularly in recent decades, is likely influenced by changing radiative forcings, of both anthropogenic and natural origin. This poses an important challenge for the detection, attribution and prediction of climate change.