Decidualization of Endometriosis in Macaques

H. M. Atkins, E. D. Lombardini, D. L. Caudell, S. E. Appt, A. Dubois, J. Mark Cline

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The decidua is the superficial portion of endometrium that transforms, or decidualizes, under the influence of progesterone to nourish the early embryo during pregnancy. Deciduae outside the uterus are found in nearly 100% of human pregnancies. This condition, known as deciduosis, may mimic malignancy, resulting in additional diagnostic procedures that place the mother, baby, or both at risk. Deciduosis has been described in both Old World and New World nonhuman primates in conjunction with pregnancy and after treatment with exogenous progestins. Here the authors present 6 cases of deciduosis associated with endometriotic lesions in female rhesus and cynomolgus macaques (Macaca mulatta and Macaca fascicularis). Full diagnostic necropsies with histologic analyses were performed on all animals. Deciduae were stained with hematoxylin and eosin and by immunohistochemistry for vimentin, CD10, progesterone receptor, estrogen receptor, desmin, cytokeratin, kermix P8, chorionic gonadotropin, human placental lactogen, and calretinin. The most common clinical signs were abdominal pain (4 of 6) and anorexia (2 of 6). At necropsy, macaque uteri were often enlarged or disfigured (4 of 6) with abundant fibrous adhesions (5 of 6). Affected tissue consisted of epithelial-lined cysts and decidualized stroma with scattered gamma/delta T cells. Decidualized stromal cells were large and polyhedral with abundant cytoplasm and round vesicular nuclei. They stained positive for vimentin, CD10, progesterone, and estrogen. In summary, these cases illustrate deciduosis in 6 nonhuman primates with endometriosis. Understanding decidualization in nonhuman primates will aid in elucidating the pathophysiology of deciduosis during pregnancy or endometriosis and potentially lead to new interventions.

Original languageEnglish (US)
Pages (from-to)1252-1258
Number of pages7
JournalVeterinary Pathology
Volume53
Issue number6
DOIs
StatePublished - Nov 1 2016

Fingerprint

Macaca
Endometriosis
Decidua
pregnancy
Primates
Pregnancy
Macaca fascicularis
vimentin
Vimentin
Macaca mulatta
uterus
Uterus
Progesterone
necropsy
progesterone
choriomammotropin
Calbindin 2
Placental Lactogen
desmin
Desmin

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Cite this

Atkins, H. M., Lombardini, E. D., Caudell, D. L., Appt, S. E., Dubois, A., & Cline, J. M. (2016). Decidualization of Endometriosis in Macaques. Veterinary Pathology, 53(6), 1252-1258. https://doi.org/10.1177/0300985816646433
Atkins, H. M. ; Lombardini, E. D. ; Caudell, D. L. ; Appt, S. E. ; Dubois, A. ; Cline, J. Mark. / Decidualization of Endometriosis in Macaques. In: Veterinary Pathology. 2016 ; Vol. 53, No. 6. pp. 1252-1258.
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Atkins, HM, Lombardini, ED, Caudell, DL, Appt, SE, Dubois, A & Cline, JM 2016, 'Decidualization of Endometriosis in Macaques', Veterinary Pathology, vol. 53, no. 6, pp. 1252-1258. https://doi.org/10.1177/0300985816646433

Decidualization of Endometriosis in Macaques. / Atkins, H. M.; Lombardini, E. D.; Caudell, D. L.; Appt, S. E.; Dubois, A.; Cline, J. Mark.

In: Veterinary Pathology, Vol. 53, No. 6, 01.11.2016, p. 1252-1258.

Research output: Contribution to journalArticle

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Atkins HM, Lombardini ED, Caudell DL, Appt SE, Dubois A, Cline JM. Decidualization of Endometriosis in Macaques. Veterinary Pathology. 2016 Nov 1;53(6):1252-1258. https://doi.org/10.1177/0300985816646433