Abstract
Phage and bacteria have engaged in a sustainable arms race, a seemingly endless conflict, since the beginning of time. CRISPR-Cas systems shape and generate environmental diversity through evolution of both predator and prey genomes. Indeed, the gain or loss of CRISPR-mediated immunity and genome maintenance can spark speciation in bacteria. Alternatively, turning CRISPR-Cas on the host by targeting chromosomal DNA has led to the development of next-generation smart antimicrobials and genetic screening and engineering technologies. Although the ability to target and cleave DNA in a sequence-specific manner is a powerful mechanism utilized by bacteria to fend off phage, plasmids, and potentially harmful nucleic acids, it is also a promising technology for programmable targeting of undesirable bacteria in microbiome consortia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 101-108 |
| Number of pages | 8 |
| Journal | Current Opinion in Microbiology |
| Volume | 31 |
| DOIs | |
| State | Published - Jun 1 2016 |
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All Science Journal Classification (ASJC) codes
- Microbiology
- Microbiology (medical)
- Infectious Diseases
Cite this
}
Deciphering and shaping bacterial diversity through CRISPR. / Briner, Alexandra E.; Barrangou, Rodolphe.
In: Current Opinion in Microbiology, Vol. 31, 01.06.2016, p. 101-108.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Deciphering and shaping bacterial diversity through CRISPR
AU - Briner, Alexandra E.
AU - Barrangou, Rodolphe
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Phage and bacteria have engaged in a sustainable arms race, a seemingly endless conflict, since the beginning of time. CRISPR-Cas systems shape and generate environmental diversity through evolution of both predator and prey genomes. Indeed, the gain or loss of CRISPR-mediated immunity and genome maintenance can spark speciation in bacteria. Alternatively, turning CRISPR-Cas on the host by targeting chromosomal DNA has led to the development of next-generation smart antimicrobials and genetic screening and engineering technologies. Although the ability to target and cleave DNA in a sequence-specific manner is a powerful mechanism utilized by bacteria to fend off phage, plasmids, and potentially harmful nucleic acids, it is also a promising technology for programmable targeting of undesirable bacteria in microbiome consortia.
AB - Phage and bacteria have engaged in a sustainable arms race, a seemingly endless conflict, since the beginning of time. CRISPR-Cas systems shape and generate environmental diversity through evolution of both predator and prey genomes. Indeed, the gain or loss of CRISPR-mediated immunity and genome maintenance can spark speciation in bacteria. Alternatively, turning CRISPR-Cas on the host by targeting chromosomal DNA has led to the development of next-generation smart antimicrobials and genetic screening and engineering technologies. Although the ability to target and cleave DNA in a sequence-specific manner is a powerful mechanism utilized by bacteria to fend off phage, plasmids, and potentially harmful nucleic acids, it is also a promising technology for programmable targeting of undesirable bacteria in microbiome consortia.
UR - http://www.scopus.com/inward/record.url?scp=84961956845&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961956845&partnerID=8YFLogxK
U2 - 10.1016/j.mib.2016.03.006
DO - 10.1016/j.mib.2016.03.006
M3 - Review article
C2 - 27045713
AN - SCOPUS:84961956845
VL - 31
SP - 101
EP - 108
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
SN - 1369-5274
ER -