Decline in bone mineral density with stress fractures in a woman on depot medroxyprogesterone acetate: A case report

Gerald J. Harkins, Gary D. Davis, Joseph Dettori, Milo L. Hibbert, Rex A. Hoyt

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

BACKGROUND: Depot medroxyprogesterone acetate is a popular contraceptive among young, physically active women. However, its administration has been linked to a relative decrease in estrogen levels. Since bone resorption is accelerated during hypoestrogenic states, there has been growing concern about the potential development of osteoporosis and fractures with the use of this contraceptive method. CASE: A physically active, 33-year-old woman demonstrated a 12.4% drop in femoral neck bone mineral density (BMD), 6.4% drop in lumbar BMD and 0.8% drop in total BMD with the subsequent development of a tibial stress fracture while on depot medroxyprogesterone acetate. Bone mineralization rapidly improved, and the stress fracture resolved with discontinuation of the medication. CONCLUSION: The long-term effects of depot medroxyprogesterone acetate on bone mineralization in physically active women should be evaluated more thoroughly.

Original languageEnglish (US)
Pages (from-to)309-312
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume44
Issue number3
StatePublished - Mar 1999

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Decline in bone mineral density with stress fractures in a woman on depot medroxyprogesterone acetate: A case report'. Together they form a unique fingerprint.

Cite this