Decline in striatal dopamine D1 and D2 receptor activation in aged F344 rats

Thomas J. Gould, Ingrid Strömberg, Paula C. Bickford

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Aging differentially affects receptor function. In the present electrophysiological study we compared neuronal responsiveness to locally applied dopamine D1 and D2 receptor agonist in the striatum of female Fischer 344 rats aged 3 and 26-27 months. In a subgroup of the old rats, the nigrostriatal dopamine bundle was destroyed unilaterally with 6-hydroxydopamine (6-OHDA) to assess receptor plasticity in response to denervation. Spontaneous firing rate of striatal neurons was higher in aged compared to young rats. Higher doses of the D1 agonist SKF 38393 or the D2 agonist quinpirole were required to elicit a 50% change in firing rate in aged compared to young rats. No difference with SKF 38393 or quinpirole was detected between 6-OHDA denervated and control (nonlesioned) striatum in aged rats. Supersensitivity to D2 agonists has been reported following 6-OHDA lesions in young rats. These observations suggest that D2 receptors in aged rat striatum might not be as plastic as in younger rats.

Original languageEnglish (US)
Pages (from-to)877-883
Number of pages7
JournalNeurobiology of Aging
Volume17
Issue number6
DOIs
StatePublished - Nov 1 1996

Fingerprint

Corpus Striatum
Dopamine D1 Receptors
Dopamine D2 Receptors
Inbred F344 Rats
Oxidopamine
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Quinpirole
Denervation
Plastics
Dopamine
Neurons

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Gould, Thomas J. ; Strömberg, Ingrid ; Bickford, Paula C. / Decline in striatal dopamine D1 and D2 receptor activation in aged F344 rats. In: Neurobiology of Aging. 1996 ; Vol. 17, No. 6. pp. 877-883.
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Decline in striatal dopamine D1 and D2 receptor activation in aged F344 rats. / Gould, Thomas J.; Strömberg, Ingrid; Bickford, Paula C.

In: Neurobiology of Aging, Vol. 17, No. 6, 01.11.1996, p. 877-883.

Research output: Contribution to journalArticle

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