Decrease in neostriatal blood flow after d-amphetamine administration or electrical stimulation of the substantia nigra

Michael H. Lavyne, Walter A. Koltun, John A. Clement, Douglas L. Rosene, Kenneth S. Pickren, Nicholas T. Zervas, Richard J. Wurtman

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Local blood flow was measured in the caudate nuclei and, in some cases, other areas of rat and monkey brain by the hydrogen clearance technique. Resting values for caudate blood flow in the rat were similar to those reported elsewhere, i.e. 69 ± 4 ml/min/100 g in the caudate. Administering d-amphetamine sulfate (0.5 mg/kg, i.p.) to rats reduced caudate flow by a maximum of about 33% after 30 min; this effect could be blocked by pretreatment with haloperidol (5.0 mg/kg, i.p.), a drug that blocks dopamine receptors. d-Amphetamine sulfate (1.5 mg/kg) also reduced caudate but not cortical blood flow in unanesthetized monkeys. Electrical stimulation of the pars compacta of the substantia nigra reduced ipsilateral caudate flow by about 25% without affecting flow in the contralateral caudate. This effect varied with the frequency and intensity of stimulation. These studies suggest that the intraparenchymal release of brain dopamine may modify intraparenchymal (local) blood flow.

Original languageEnglish (US)
Pages (from-to)77-86
Number of pages10
JournalBrain research
Volume135
Issue number1
DOIs
StatePublished - Oct 21 1977

Fingerprint

Dextroamphetamine
Substantia Nigra
Electric Stimulation
Haplorhini
Caudate Nucleus
Dopamine Receptors
Brain
Haloperidol
Hydrogen
Dopamine
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Lavyne, Michael H. ; Koltun, Walter A. ; Clement, John A. ; Rosene, Douglas L. ; Pickren, Kenneth S. ; Zervas, Nicholas T. ; Wurtman, Richard J. / Decrease in neostriatal blood flow after d-amphetamine administration or electrical stimulation of the substantia nigra. In: Brain research. 1977 ; Vol. 135, No. 1. pp. 77-86.
@article{00f67c48e91f4d48aa037d842ac8adfc,
title = "Decrease in neostriatal blood flow after d-amphetamine administration or electrical stimulation of the substantia nigra",
abstract = "Local blood flow was measured in the caudate nuclei and, in some cases, other areas of rat and monkey brain by the hydrogen clearance technique. Resting values for caudate blood flow in the rat were similar to those reported elsewhere, i.e. 69 ± 4 ml/min/100 g in the caudate. Administering d-amphetamine sulfate (0.5 mg/kg, i.p.) to rats reduced caudate flow by a maximum of about 33{\%} after 30 min; this effect could be blocked by pretreatment with haloperidol (5.0 mg/kg, i.p.), a drug that blocks dopamine receptors. d-Amphetamine sulfate (1.5 mg/kg) also reduced caudate but not cortical blood flow in unanesthetized monkeys. Electrical stimulation of the pars compacta of the substantia nigra reduced ipsilateral caudate flow by about 25{\%} without affecting flow in the contralateral caudate. This effect varied with the frequency and intensity of stimulation. These studies suggest that the intraparenchymal release of brain dopamine may modify intraparenchymal (local) blood flow.",
author = "Lavyne, {Michael H.} and Koltun, {Walter A.} and Clement, {John A.} and Rosene, {Douglas L.} and Pickren, {Kenneth S.} and Zervas, {Nicholas T.} and Wurtman, {Richard J.}",
year = "1977",
month = "10",
day = "21",
doi = "10.1016/0006-8993(77)91053-8",
language = "English (US)",
volume = "135",
pages = "77--86",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

Decrease in neostriatal blood flow after d-amphetamine administration or electrical stimulation of the substantia nigra. / Lavyne, Michael H.; Koltun, Walter A.; Clement, John A.; Rosene, Douglas L.; Pickren, Kenneth S.; Zervas, Nicholas T.; Wurtman, Richard J.

In: Brain research, Vol. 135, No. 1, 21.10.1977, p. 77-86.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Decrease in neostriatal blood flow after d-amphetamine administration or electrical stimulation of the substantia nigra

AU - Lavyne, Michael H.

AU - Koltun, Walter A.

AU - Clement, John A.

AU - Rosene, Douglas L.

AU - Pickren, Kenneth S.

AU - Zervas, Nicholas T.

AU - Wurtman, Richard J.

PY - 1977/10/21

Y1 - 1977/10/21

N2 - Local blood flow was measured in the caudate nuclei and, in some cases, other areas of rat and monkey brain by the hydrogen clearance technique. Resting values for caudate blood flow in the rat were similar to those reported elsewhere, i.e. 69 ± 4 ml/min/100 g in the caudate. Administering d-amphetamine sulfate (0.5 mg/kg, i.p.) to rats reduced caudate flow by a maximum of about 33% after 30 min; this effect could be blocked by pretreatment with haloperidol (5.0 mg/kg, i.p.), a drug that blocks dopamine receptors. d-Amphetamine sulfate (1.5 mg/kg) also reduced caudate but not cortical blood flow in unanesthetized monkeys. Electrical stimulation of the pars compacta of the substantia nigra reduced ipsilateral caudate flow by about 25% without affecting flow in the contralateral caudate. This effect varied with the frequency and intensity of stimulation. These studies suggest that the intraparenchymal release of brain dopamine may modify intraparenchymal (local) blood flow.

AB - Local blood flow was measured in the caudate nuclei and, in some cases, other areas of rat and monkey brain by the hydrogen clearance technique. Resting values for caudate blood flow in the rat were similar to those reported elsewhere, i.e. 69 ± 4 ml/min/100 g in the caudate. Administering d-amphetamine sulfate (0.5 mg/kg, i.p.) to rats reduced caudate flow by a maximum of about 33% after 30 min; this effect could be blocked by pretreatment with haloperidol (5.0 mg/kg, i.p.), a drug that blocks dopamine receptors. d-Amphetamine sulfate (1.5 mg/kg) also reduced caudate but not cortical blood flow in unanesthetized monkeys. Electrical stimulation of the pars compacta of the substantia nigra reduced ipsilateral caudate flow by about 25% without affecting flow in the contralateral caudate. This effect varied with the frequency and intensity of stimulation. These studies suggest that the intraparenchymal release of brain dopamine may modify intraparenchymal (local) blood flow.

UR - http://www.scopus.com/inward/record.url?scp=0017724596&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017724596&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(77)91053-8

DO - 10.1016/0006-8993(77)91053-8

M3 - Article

C2 - 410481

AN - SCOPUS:0017724596

VL - 135

SP - 77

EP - 86

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -