Decrease in RNA folding cooperativity by deliberate population of intermediates in RNA G-quadruplexes

Chun Kit Kwok, Madeline E. Sherlock, Philip C. Bevilacqua

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Keeping a broad (RNA) perspective: Conventional biochemical detection systems only have a 100-fold linear response range. The range of potassium concentrations detected by an RNA G-quadruplex sequence can be broadened by intentionally populating multiple intermediate folding states (see scheme). The folding of the RNA G-quadruplexes was monitored by both circular dichroism and intrinsic fluorescence spectroscopy.

Original languageEnglish (US)
Pages (from-to)683-686
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number2
DOIs
StatePublished - Jan 7 2013

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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