Decreased behavioral effects of daily intracerebroventricular bombesin

R. L. Corwin; E. S. Corp; J. Gibbs; G. P. Smith

doi:10.1016/0196-9781(92)90031-W

Decreased behavioral effects of daily intracerebroventricular bombesin

R. L. Corwin, E. S. Corp, J. Gibbs, G. P. Smith

Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Intracerebroventricular (ICV) bombesin increases grooming and decreases food intake in rats. We examined tolerance to these effects by administering a daily injection of either saline or 25 ng bombesin to rats for 8 days via lateral ventricular cannulas. Food intake and grooming were monitored. After 8 days bombesin no longer increased grooming or decreased food intake in bombesin-treated rats, but did increase grooming and decrease food intake in saline-treated rats. This development of behavioral tolerance conflicts with previous reports using larger doses and demonstrates that repeated small doses of ICV bombesin produce different effects from larger doses.

Original language	English (US)
Pages (from-to)	1215-1218
Number of pages	4
Journal	Peptides
Volume	13
Issue number	6
DOIs	https://doi.org/10.1016/0196-9781(92)90031-W
State	Published - 1992

All Science Journal Classification (ASJC) codes

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/0196-9781(92)90031-W

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title = "Decreased behavioral effects of daily intracerebroventricular bombesin",

abstract = "Intracerebroventricular (ICV) bombesin increases grooming and decreases food intake in rats. We examined tolerance to these effects by administering a daily injection of either saline or 25 ng bombesin to rats for 8 days via lateral ventricular cannulas. Food intake and grooming were monitored. After 8 days bombesin no longer increased grooming or decreased food intake in bombesin-treated rats, but did increase grooming and decrease food intake in saline-treated rats. This development of behavioral tolerance conflicts with previous reports using larger doses and demonstrates that repeated small doses of ICV bombesin produce different effects from larger doses.",

author = "Corwin, {R. L.} and Corp, {E. S.} and J. Gibbs and Smith, {G. P.}",

note = "Funding Information: ACKNOWLEDGEMENTS The authors gratefully acknowledge the technical assistance of Marshall Curson and the statistical advice of Richard Shindledecker. Supported by USPHS Grant DK33248 (J.G.), NIMH RSA MK00149 (G.P.S.), and The New York Obesity Center (R.L.C.).",

year = "1992",

doi = "10.1016/0196-9781(92)90031-W",

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T1 - Decreased behavioral effects of daily intracerebroventricular bombesin

AU - Corwin, R. L.

AU - Corp, E. S.

AU - Gibbs, J.

AU - Smith, G. P.

N1 - Funding Information: ACKNOWLEDGEMENTS The authors gratefully acknowledge the technical assistance of Marshall Curson and the statistical advice of Richard Shindledecker. Supported by USPHS Grant DK33248 (J.G.), NIMH RSA MK00149 (G.P.S.), and The New York Obesity Center (R.L.C.).

PY - 1992

Y1 - 1992

N2 - Intracerebroventricular (ICV) bombesin increases grooming and decreases food intake in rats. We examined tolerance to these effects by administering a daily injection of either saline or 25 ng bombesin to rats for 8 days via lateral ventricular cannulas. Food intake and grooming were monitored. After 8 days bombesin no longer increased grooming or decreased food intake in bombesin-treated rats, but did increase grooming and decrease food intake in saline-treated rats. This development of behavioral tolerance conflicts with previous reports using larger doses and demonstrates that repeated small doses of ICV bombesin produce different effects from larger doses.

AB - Intracerebroventricular (ICV) bombesin increases grooming and decreases food intake in rats. We examined tolerance to these effects by administering a daily injection of either saline or 25 ng bombesin to rats for 8 days via lateral ventricular cannulas. Food intake and grooming were monitored. After 8 days bombesin no longer increased grooming or decreased food intake in bombesin-treated rats, but did increase grooming and decrease food intake in saline-treated rats. This development of behavioral tolerance conflicts with previous reports using larger doses and demonstrates that repeated small doses of ICV bombesin produce different effects from larger doses.

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Decreased behavioral effects of daily intracerebroventricular bombesin

Abstract

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