Decreased behavioral effects of daily intracerebroventricular bombesin

R. L. Corwin, E. S. Corp, J. Gibbs, G. P. Smith

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Intracerebroventricular (ICV) bombesin increases grooming and decreases food intake in rats. We examined tolerance to these effects by administering a daily injection of either saline or 25 ng bombesin to rats for 8 days via lateral ventricular cannulas. Food intake and grooming were monitored. After 8 days bombesin no longer increased grooming or decreased food intake in bombesin-treated rats, but did increase grooming and decrease food intake in saline-treated rats. This development of behavioral tolerance conflicts with previous reports using larger doses and demonstrates that repeated small doses of ICV bombesin produce different effects from larger doses.

Original languageEnglish (US)
Pages (from-to)1215-1218
Number of pages4
Issue number6
StatePublished - 1992

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience


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