Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease

Ian A. Simpson, Koteswara R. Chundu, Theresa Davies‐Hill, William G. Honer, Peter Davies

Research output: Contribution to journalArticlepeer-review

295 Scopus citations

Abstract

Glucose metabolism is depressed in the temporal and parietal regions of the cortex in patients with Alzheimer's disease. We measured the concentrations of two glucose transporters, GLUT1 and GLUT3, in six regions of brains from both control subjects and patients with Alzheimer's disease. The concentrations of both transporters were reduced in the cerebral cortex, with larger and highly significant reductions observed for GLUT3, the putative neuronal glucose transporter. The reductions in GLUT3 were greater than the loss of synapses, and should be considered as a potential cause of the deficits in glucose metabolism.

Original languageEnglish (US)
Pages (from-to)546-551
Number of pages6
JournalAnnals of Neurology
Volume35
Issue number5
DOIs
StatePublished - May 1994

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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