Decreased expression of the human progenitor cell antigen (CD34) in morphea

K. Skobieranda, Klaus Helm

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Morphea is an idiopathic disorder the hallmark of which is fibrosis of the skin. The regulatory factors resulting in the increased collagen production have not been determined. Within the dermis there are dendritic cells with possible immunological functions that express either the human progenitor cell antigen (CD34) or factor XIIIa. Immunohistochemical stains for factor XIIIa, CD34, S100, proliferating nuclear cell antigen, and vimentin were performed on 26 skin biopsies from patients with morphea and 11 biopsies from normal skin. A decreased number of CD34-expressing cells was seen in the affected skin from morphea patients, while there was an increased number of cells expressing factor XIIIa and vimentin. We hypothesize that CD34-positive dendritic cells may have a regulatory role in collagen synthesis and that lack of CD34 expression can be used as a marker for morphea.

Original languageEnglish (US)
Pages (from-to)471-475
Number of pages5
JournalAmerican Journal of Dermatopathology
Volume17
Issue number5
DOIs
StatePublished - Jan 1 1995

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CD34 Antigens
Localized Scleroderma
Factor XIIIa
Stem Cells
Skin
Vimentin
Dendritic Cells
Collagen
Biopsy
Proliferating Cell Nuclear Antigen
Dermis
Fibrosis
Coloring Agents
Cell Count

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Dermatology

Cite this

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abstract = "Morphea is an idiopathic disorder the hallmark of which is fibrosis of the skin. The regulatory factors resulting in the increased collagen production have not been determined. Within the dermis there are dendritic cells with possible immunological functions that express either the human progenitor cell antigen (CD34) or factor XIIIa. Immunohistochemical stains for factor XIIIa, CD34, S100, proliferating nuclear cell antigen, and vimentin were performed on 26 skin biopsies from patients with morphea and 11 biopsies from normal skin. A decreased number of CD34-expressing cells was seen in the affected skin from morphea patients, while there was an increased number of cells expressing factor XIIIa and vimentin. We hypothesize that CD34-positive dendritic cells may have a regulatory role in collagen synthesis and that lack of CD34 expression can be used as a marker for morphea.",
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Decreased expression of the human progenitor cell antigen (CD34) in morphea. / Skobieranda, K.; Helm, Klaus.

In: American Journal of Dermatopathology, Vol. 17, No. 5, 01.01.1995, p. 471-475.

Research output: Contribution to journalArticle

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