TY - JOUR
T1 - Decreased pokeweed mitogen‐induced igm and igm rheumatoid factor synthesis in rheumatoid arthritis patients treated with gold sodium thiomalate or penicillamine
AU - Olsen, Nancy
AU - Jasin, Hugo E.
PY - 1984/1/1
Y1 - 1984/1/1
N2 - Prospective and retrospective analysis of data obtained on 119 patients with rheumatoid arthritis suggested a relationship between clinical response induced by gold salts or D‐penicillamine and decreased in vitro antibody synthesis by peripheral blood mononuclear cells. A subgroup of 21 patients with inactive disease receiving these drugs was found to have decreased pokeweed mitogen‐induced in vitro synthesis of IgM and IgM rheumatoid factor. Detailed analysis of the cellular mechanisms responsible for this decreased responsiveness demonstrated markedly decreased B cell function. Patients treated with D‐penicillamine also had altered T cell helper function manifested by incomplete reconstitution of the normal IgM response, while patients treated with gold salts had normal T cell function. Monocytes appeared not to have a major role in the decreased in vitro responsiveness. The results suggest that, in patients who respond to gold salts or D‐penicillamine, antibody synthesis by circulating B cells is profoundly decreased, probably due to an indirect effect of these disease‐modifying agents.
AB - Prospective and retrospective analysis of data obtained on 119 patients with rheumatoid arthritis suggested a relationship between clinical response induced by gold salts or D‐penicillamine and decreased in vitro antibody synthesis by peripheral blood mononuclear cells. A subgroup of 21 patients with inactive disease receiving these drugs was found to have decreased pokeweed mitogen‐induced in vitro synthesis of IgM and IgM rheumatoid factor. Detailed analysis of the cellular mechanisms responsible for this decreased responsiveness demonstrated markedly decreased B cell function. Patients treated with D‐penicillamine also had altered T cell helper function manifested by incomplete reconstitution of the normal IgM response, while patients treated with gold salts had normal T cell function. Monocytes appeared not to have a major role in the decreased in vitro responsiveness. The results suggest that, in patients who respond to gold salts or D‐penicillamine, antibody synthesis by circulating B cells is profoundly decreased, probably due to an indirect effect of these disease‐modifying agents.
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U2 - 10.1002/art.1780270904
DO - 10.1002/art.1780270904
M3 - Article
C2 - 6433938
AN - SCOPUS:0021203692
VL - 27
SP - 985
EP - 994
JO - Arthritis and Rheumatology
JF - Arthritis and Rheumatology
SN - 2326-5191
IS - 9
ER -