Decreased susceptibility to seizures induced by bicuculline after transient bilateral clamping of the carotid arteries in rats

M. Sieklucka, Z. Bortolotto, C. Heim, F. Block, K. H. Sontag

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Rats were exposed for 24 min to bilateral clamping of the common carotid arteries (BCCA) in pentobarbital anaesthesia. 14 days later the animals were subjected to subcutaneous injection of (+)-bicuculline (3 or 4 mg/kg). A significantly decreased susceptibility to bicuculline-induced seizures could be observed in BCCA treated rats compared with sham operated controls. It is suggested that BCCA treatment protects animals against status epilepticus and lethal toxicity produced by bicuculline. Electrographic recordings of the BCCA animals revealed no ictal activity within 1 h after bicuculline injection. An analysis of the GABA content showed a significant increase in the hippocampus (HPC), frontal cortex (FCX), parietal cortex and substantia nigra in BCCA animals compared with controls. It is therefore possible that an increase in GABA content postsynaptically counteracts the GABAA antagonistic effect of bicuculline in BCCA animals thus preventing the normal seizure inducing effect of this substance.

Original languageEnglish (US)
Pages (from-to)127-137
Number of pages11
JournalJournal of Neural Transmission
Volume83
Issue number1-2
DOIs
StatePublished - Feb 1 1991

Fingerprint

Bicuculline
Common Carotid Artery
Carotid Arteries
Constriction
Seizures
gamma-Aminobutyric Acid
Parietal Lobe
Status Epilepticus
Frontal Lobe
Substantia Nigra
Pentobarbital
Subcutaneous Injections
Hippocampus
Anesthesia
Stroke
Injections

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

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abstract = "Rats were exposed for 24 min to bilateral clamping of the common carotid arteries (BCCA) in pentobarbital anaesthesia. 14 days later the animals were subjected to subcutaneous injection of (+)-bicuculline (3 or 4 mg/kg). A significantly decreased susceptibility to bicuculline-induced seizures could be observed in BCCA treated rats compared with sham operated controls. It is suggested that BCCA treatment protects animals against status epilepticus and lethal toxicity produced by bicuculline. Electrographic recordings of the BCCA animals revealed no ictal activity within 1 h after bicuculline injection. An analysis of the GABA content showed a significant increase in the hippocampus (HPC), frontal cortex (FCX), parietal cortex and substantia nigra in BCCA animals compared with controls. It is therefore possible that an increase in GABA content postsynaptically counteracts the GABAA antagonistic effect of bicuculline in BCCA animals thus preventing the normal seizure inducing effect of this substance.",
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Decreased susceptibility to seizures induced by bicuculline after transient bilateral clamping of the carotid arteries in rats. / Sieklucka, M.; Bortolotto, Z.; Heim, C.; Block, F.; Sontag, K. H.

In: Journal of Neural Transmission, Vol. 83, No. 1-2, 01.02.1991, p. 127-137.

Research output: Contribution to journalArticle

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AU - Bortolotto, Z.

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