Dedifferentiated epithelial-myoepithelial carcinoma: Analysis of a rare entity based on a case report and literature review

Aaron R. Baker, Sara E. Ohanessian, Eelam Adil, Henry Crist, David Goldenberg, Haresh Mani

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Dedifferentiated epithelial-myoepithelial carcinoma (DEMC) is very rare salivary gland neoplasm with only anecdotal reports. We present an analysis of DEMC, based on a case and review of literature. Our patient, an 85-year-old woman, presented with a submandibular mass of 5 years duration that was increasing in size over a 5-week period. Histologically, there were areas of typical epithelial-myoepithelial carcinoma, with dedifferentiation of both components, manifesting morphologically as salivary duct carcinoma and areas of myoepithelial carcinoma. A review of literature revealed 21 previously reported cases of DEMC. DEMC occurs at an average age of 72 years, most often in the parotid gland (72%) followed by submandibular gland (17%). Dedifferentiation more often involves the epithelial component (13/15 cases) than the myoepithelial component (5/15 cases). Although typical epithelial-myoepithelial carcinomas are fairly indolent (average disease-free survival of 11.34 years), dedifferentiation confers a poor prognosis (survival reported from 1 to 72 months).

Original languageEnglish (US)
Pages (from-to)514-519
Number of pages6
JournalInternational Journal of Surgical Pathology
Volume21
Issue number5
DOIs
StatePublished - Oct 1 2013

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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