Dedifferentiated epithelial-myoepithelial carcinoma

Analysis of a rare entity based on a case report and literature review

Aaron R. Baker, Sara E. Ohanessian, Eelam Adil, Henry Crist, David Goldenberg, Haresh Mani

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Dedifferentiated epithelial-myoepithelial carcinoma (DEMC) is very rare salivary gland neoplasm with only anecdotal reports. We present an analysis of DEMC, based on a case and review of literature. Our patient, an 85-year-old woman, presented with a submandibular mass of 5 years duration that was increasing in size over a 5-week period. Histologically, there were areas of typical epithelial-myoepithelial carcinoma, with dedifferentiation of both components, manifesting morphologically as salivary duct carcinoma and areas of myoepithelial carcinoma. A review of literature revealed 21 previously reported cases of DEMC. DEMC occurs at an average age of 72 years, most often in the parotid gland (72%) followed by submandibular gland (17%). Dedifferentiation more often involves the epithelial component (13/15 cases) than the myoepithelial component (5/15 cases). Although typical epithelial-myoepithelial carcinomas are fairly indolent (average disease-free survival of 11.34 years), dedifferentiation confers a poor prognosis (survival reported from 1 to 72 months).

Original languageEnglish (US)
Pages (from-to)514-519
Number of pages6
JournalInternational Journal of Surgical Pathology
Volume21
Issue number5
DOIs
StatePublished - Oct 1 2013

Fingerprint

Carcinoma
Salivary Gland Neoplasms
Salivary Ducts
Submandibular Gland
Parotid Gland
Disease-Free Survival
Survival

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

@article{56a4cbf7a546435d89228f46bc6eb220,
title = "Dedifferentiated epithelial-myoepithelial carcinoma: Analysis of a rare entity based on a case report and literature review",
abstract = "Dedifferentiated epithelial-myoepithelial carcinoma (DEMC) is very rare salivary gland neoplasm with only anecdotal reports. We present an analysis of DEMC, based on a case and review of literature. Our patient, an 85-year-old woman, presented with a submandibular mass of 5 years duration that was increasing in size over a 5-week period. Histologically, there were areas of typical epithelial-myoepithelial carcinoma, with dedifferentiation of both components, manifesting morphologically as salivary duct carcinoma and areas of myoepithelial carcinoma. A review of literature revealed 21 previously reported cases of DEMC. DEMC occurs at an average age of 72 years, most often in the parotid gland (72{\%}) followed by submandibular gland (17{\%}). Dedifferentiation more often involves the epithelial component (13/15 cases) than the myoepithelial component (5/15 cases). Although typical epithelial-myoepithelial carcinomas are fairly indolent (average disease-free survival of 11.34 years), dedifferentiation confers a poor prognosis (survival reported from 1 to 72 months).",
author = "Baker, {Aaron R.} and Ohanessian, {Sara E.} and Eelam Adil and Henry Crist and David Goldenberg and Haresh Mani",
year = "2013",
month = "10",
day = "1",
doi = "10.1177/1066896912468153",
language = "English (US)",
volume = "21",
pages = "514--519",
journal = "International Journal of Surgical Pathology",
issn = "1066-8969",
publisher = "SAGE Publications Inc.",
number = "5",

}

Dedifferentiated epithelial-myoepithelial carcinoma : Analysis of a rare entity based on a case report and literature review. / Baker, Aaron R.; Ohanessian, Sara E.; Adil, Eelam; Crist, Henry; Goldenberg, David; Mani, Haresh.

In: International Journal of Surgical Pathology, Vol. 21, No. 5, 01.10.2013, p. 514-519.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Dedifferentiated epithelial-myoepithelial carcinoma

T2 - Analysis of a rare entity based on a case report and literature review

AU - Baker, Aaron R.

AU - Ohanessian, Sara E.

AU - Adil, Eelam

AU - Crist, Henry

AU - Goldenberg, David

AU - Mani, Haresh

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Dedifferentiated epithelial-myoepithelial carcinoma (DEMC) is very rare salivary gland neoplasm with only anecdotal reports. We present an analysis of DEMC, based on a case and review of literature. Our patient, an 85-year-old woman, presented with a submandibular mass of 5 years duration that was increasing in size over a 5-week period. Histologically, there were areas of typical epithelial-myoepithelial carcinoma, with dedifferentiation of both components, manifesting morphologically as salivary duct carcinoma and areas of myoepithelial carcinoma. A review of literature revealed 21 previously reported cases of DEMC. DEMC occurs at an average age of 72 years, most often in the parotid gland (72%) followed by submandibular gland (17%). Dedifferentiation more often involves the epithelial component (13/15 cases) than the myoepithelial component (5/15 cases). Although typical epithelial-myoepithelial carcinomas are fairly indolent (average disease-free survival of 11.34 years), dedifferentiation confers a poor prognosis (survival reported from 1 to 72 months).

AB - Dedifferentiated epithelial-myoepithelial carcinoma (DEMC) is very rare salivary gland neoplasm with only anecdotal reports. We present an analysis of DEMC, based on a case and review of literature. Our patient, an 85-year-old woman, presented with a submandibular mass of 5 years duration that was increasing in size over a 5-week period. Histologically, there were areas of typical epithelial-myoepithelial carcinoma, with dedifferentiation of both components, manifesting morphologically as salivary duct carcinoma and areas of myoepithelial carcinoma. A review of literature revealed 21 previously reported cases of DEMC. DEMC occurs at an average age of 72 years, most often in the parotid gland (72%) followed by submandibular gland (17%). Dedifferentiation more often involves the epithelial component (13/15 cases) than the myoepithelial component (5/15 cases). Although typical epithelial-myoepithelial carcinomas are fairly indolent (average disease-free survival of 11.34 years), dedifferentiation confers a poor prognosis (survival reported from 1 to 72 months).

UR - http://www.scopus.com/inward/record.url?scp=84880834600&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880834600&partnerID=8YFLogxK

U2 - 10.1177/1066896912468153

DO - 10.1177/1066896912468153

M3 - Article

VL - 21

SP - 514

EP - 519

JO - International Journal of Surgical Pathology

JF - International Journal of Surgical Pathology

SN - 1066-8969

IS - 5

ER -