Deep adversarial networks for biomedical image segmentation utilizing unannotated images

Yizhe Zhang, Lin Yang, Jianxu Chen, Maridel Fredericksen, David P. Hughes, Danny Z. Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

43 Scopus citations

Abstract

Semantic segmentation is a fundamental problem in biomedical image analysis. In biomedical practice, it is often the case that only limited annotated data are available for model training. Unannotated images, on the other hand, are easier to acquire. How to utilize unannotated images for training effective segmentation models is an important issue. In this paper, we propose a new deep adversarial network (DAN) model for biomedical image segmentation, aiming to attain consistently good segmentation results on both annotated and unannotated images. Our model consists of two networks: (1) a segmentation network (SN) to conduct segmentation; (2) an evaluation network (EN) to assess segmentation quality. During training, EN is encouraged to distinguish between segmentation results of unannotated images and annotated ones (by giving them different scores), while SN is encouraged to produce segmentation results of unannotated images such that EN cannot distinguish these from the annotated ones. Through an iterative adversarial training process, because EN is constantly “criticizing” the segmentation results of unannotated images, SN can be trained to produce more and more accurate segmentation for unannotated and unseen samples. Experiments show that our proposed DAN model is effective in utilizing unannotated image data to obtain considerably better segmentation.

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer Assisted Intervention − MICCAI 2017 - 20th International Conference, Proceedings
EditorsLena Maier-Hein, Alfred Franz, Pierre Jannin, Simon Duchesne, Maxime Descoteaux, D. Louis Collins
PublisherSpringer Verlag
Pages408-416
Number of pages9
ISBN (Print)9783319661780
DOIs
StatePublished - Jan 1 2017
Event20th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2017 - Quebec City, Canada
Duration: Sep 11 2017Sep 13 2017

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume10435 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other20th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2017
CountryCanada
CityQuebec City
Period9/11/179/13/17

All Science Journal Classification (ASJC) codes

  • Theoretical Computer Science
  • Computer Science(all)

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  • Cite this

    Zhang, Y., Yang, L., Chen, J., Fredericksen, M., Hughes, D. P., & Chen, D. Z. (2017). Deep adversarial networks for biomedical image segmentation utilizing unannotated images. In L. Maier-Hein, A. Franz, P. Jannin, S. Duchesne, M. Descoteaux, & D. L. Collins (Eds.), Medical Image Computing and Computer Assisted Intervention − MICCAI 2017 - 20th International Conference, Proceedings (pp. 408-416). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 10435 LNCS). Springer Verlag. https://doi.org/10.1007/978-3-319-66179-7_47