Deep tissue photoacoustic imaging using a miniaturized 2-D capacitive micromachined ultrasonic transducer array

Sri-Rajasekhar Kothapalli, Te Jen Ma, Srikant Vaithilingam, Ömer Oralkan, Butrus T. Khuri-Yakub, Sanjiv Sam Gambhir

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

In this paper, we demonstrate 3-D photoacoustic imaging (PAI) of light absorbing objects embedded as deep as 5 cm inside strong optically scattering phantoms using a miniaturized (4 mm × 4 mm × 500 m), 2-D capacitive micromachined ultrasonic transducer (CMUT) array of 16 × 16 elements with a center frequency of 5.5 MHz. Two-dimensional tomographic images and 3-D volumetric images of the objects placed at different depths are presented. In addition, we studied the sensitivity of CMUT-based PAI to the concentration of indocyanine green dye at 5 cm depth inside the phantom. Under optimized experimental conditions, the objects at 5 cm depth can be imaged with SNR of about 35 dB and a spatial resolution of approximately 500 μm. Results demonstrate that CMUTs with integrated front-end amplifier circuits are an attractive choice for achieving relatively high depth sensitivity for PAI.

Original languageEnglish (US)
Article number6129397
Pages (from-to)1199-1204
Number of pages6
JournalIEEE Transactions on Biomedical Engineering
Volume59
Issue number5
DOIs
StatePublished - May 1 2012

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Ultrasonic transducers
Photoacoustic effect
Tissue
Imaging techniques
Dyes
Scattering
Networks (circuits)

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Cite this

Kothapalli, Sri-Rajasekhar ; Ma, Te Jen ; Vaithilingam, Srikant ; Oralkan, Ömer ; Khuri-Yakub, Butrus T. ; Gambhir, Sanjiv Sam. / Deep tissue photoacoustic imaging using a miniaturized 2-D capacitive micromachined ultrasonic transducer array. In: IEEE Transactions on Biomedical Engineering. 2012 ; Vol. 59, No. 5. pp. 1199-1204.
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Deep tissue photoacoustic imaging using a miniaturized 2-D capacitive micromachined ultrasonic transducer array. / Kothapalli, Sri-Rajasekhar; Ma, Te Jen; Vaithilingam, Srikant; Oralkan, Ömer; Khuri-Yakub, Butrus T.; Gambhir, Sanjiv Sam.

In: IEEE Transactions on Biomedical Engineering, Vol. 59, No. 5, 6129397, 01.05.2012, p. 1199-1204.

Research output: Contribution to journalArticle

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