Deep tissue photoacoustic imaging using a miniaturized 2-D capacitive micromachined ultrasonic transducer array

Sri Rajasekhar Kothapalli, Te Jen Ma, Srikant Vaithilingam, Ömer Oralkan, Butrus T. Khuri-Yakub, Sanjiv Sam Gambhir

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

In this paper, we demonstrate 3-D photoacoustic imaging (PAI) of light absorbing objects embedded as deep as 5 cm inside strong optically scattering phantoms using a miniaturized (4 mm × 4 mm × 500 m), 2-D capacitive micromachined ultrasonic transducer (CMUT) array of 16 × 16 elements with a center frequency of 5.5 MHz. Two-dimensional tomographic images and 3-D volumetric images of the objects placed at different depths are presented. In addition, we studied the sensitivity of CMUT-based PAI to the concentration of indocyanine green dye at 5 cm depth inside the phantom. Under optimized experimental conditions, the objects at 5 cm depth can be imaged with SNR of about 35 dB and a spatial resolution of approximately 500 μm. Results demonstrate that CMUTs with integrated front-end amplifier circuits are an attractive choice for achieving relatively high depth sensitivity for PAI.

Original languageEnglish (US)
Article number6129397
Pages (from-to)1199-1204
Number of pages6
JournalIEEE Transactions on Biomedical Engineering
Volume59
Issue number5
DOIs
StatePublished - May 2012

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

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